並列タイトル等頭頸部癌細胞におけるレスベラトロールのREG III発現誘導効果と癌の進展抑制・治療向上効果
タイトル（掲載誌）International journal of oncology
一般注記type:Thesis
Identification of reliable markers of chemo- and radiosensitivity and the key molecules that enhance the susceptibility of head and neck squamous cell carcinoma (HNSCC) to anticancer treatments is highly desirable. Previously, we have reported that regenerating gene (REG) Ⅲ expression was such a marker associated with an improved survival rate for HNSCC patients. In the present study, we investigated the stimulators for induction of REG Ⅲ expression using REG Ⅲ promoter assay in HNSCC cells transfected with REG Ⅲ promoter vector. We tested inflammatory cytokines, growth factors, polyphenols, PPARγ activator of thiazolidinediones, and histone deacetylase inhibitors, and found that 3,4',5-trihydroxy-trans-stilbene (resveratrol) significantly increased the REG Ⅲ promoter activity and the mRNA levels of REG Ⅲ in HNSCC cells. Moreover, we demonstrated the effect of resveratrol on cancer cell progression, such as cell proliferation, chemo‑ and radiosensitivity and cancer invasion of HNSCC cells. Resveratrol significantly inhibited cell growth, enhanced chemo‑ and radiosensitivity, and blocked cancer invasion of HNSCC cells. These data suggested that resveratrol could inhibit cancer progression through the REG Ⅲ expression pathway in HNSCC cells.
博士（医学）・甲第682号・平成30年3月15日
Copyright © Spandidos Publications 2017. All rights reserved.
The Spandidos Publications link is available at " https://doi.org/10.3892/ijo.2016.3664 "
identifier:International journal of oncology Vol.49 No.4 p.1553-1560 (2016 Oct)
identifier:10196439
identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3427
identifier:International journal of oncology, 49(4): 1553-1560
DOIinfo:doi/10.3892/ijo.2016.3664
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