Effect of resveratrol on cancer progression through the REG Ⅲ expression pathway in head and neck cancer cells.

• Material Type: 博士論文
• ISSN: 1019-6439
• Title: Effect of resveratrol on cancer progression through the REG Ⅲ expression pathway in head and neck cancer cells.
• Volume: 49 4
• Author/Editor: Mikami, Shinji; Ota, Ichiro; Masui, Takashi; Itaya-Hironaka, Asako; Shobatake, Ryogo; Okamoto, Hideyuki; Takasawa, Shin; Kitahara, Tadashi
• Author Heading: Mikami, Shinji; Ota, Ichiro; Masui, Takashi; Itaya-Hironaka, Asako; Shobatake, Ryogo; Okamoto, Hideyuki; Takasawa, Shin; Kitahara, Tadashi
• Publication, Distribution, etc.: Spandidos Publications
• Publication Date: 2016-10; 49 4
• Publication Date (W3CDTF): 2016-10
• Alternative Title: 頭頸部癌細胞におけるレスベラトロールのREG III発現誘導効果と癌の進展抑制・治療向上効果
• Periodical title: International journal of oncology
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2018-03-15
• Date Granted (W3CDTF): 2018-03-15
• Dissertation Number: 甲第682号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第682号
• Text Language Code: eng
• Subject Heading: polyphenol; regenerating gene family; head and neck; squamous cell carcinoma; chemosensitivity; radiosensitivity
• Target Audience: 一般
• Note (General): type:Thesis; Identification of reliable markers of chemo- and radiosensitivity and the key molecules that enhance the susceptibility of head and neck squamous cell carcinoma (HNSCC) to anticancer treatments is highly desirable. Previously, we have reported that regenerating gene (REG) Ⅲ expression was such a marker associated with an improved survival rate for HNSCC patients. In the present study, we investigated the stimulators for induction of REG Ⅲ expression using REG Ⅲ promoter assay in HNSCC cells transfected with REG Ⅲ promoter vector. We tested inflammatory cytokines, growth factors, polyphenols, PPARγ activator of thiazolidinediones, and histone deacetylase inhibitors, and found that 3,4',5-trihydroxy-trans-stilbene (resveratrol) significantly increased the REG Ⅲ promoter activity and the mRNA levels of REG Ⅲ in HNSCC cells. Moreover, we demonstrated the effect of resveratrol on cancer cell progression, such as cell proliferation, chemo‑ and radiosensitivity and cancer invasion of HNSCC cells. Resveratrol significantly inhibited cell growth, enhanced chemo‑ and radiosensitivity, and blocked cancer invasion of HNSCC cells. These data suggested that resveratrol could inhibit cancer progression through the REG Ⅲ expression pathway in HNSCC cells.; 博士（医学）・甲第682号・平成30年3月15日; Copyright © Spandidos Publications 2017. All rights reserved.; The Spandidos Publications link is available at " https://doi.org/10.3892/ijo.2016.3664 "; identifier:International journal of oncology Vol.49 No.4 p.1553-1560 (2016 Oct); identifier:10196439; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3427; identifier:International journal of oncology, 49(4): 1553-1560
• DOI: info:doi/10.3892/ijo.2016.3664; https://doi.org/info:doi/10.3892/ijo.2016.3664
• Persistent ID (NDL): info:ndljp/pid/11092082; https://dl.ndl.go.jp/pid/11092082
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2018-05-04T12:13:37+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10564/3427
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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