並列タイトル等ムスカリン性アセチルコリン受容体によるJNKの活性化はマウス腸管における分泌を負に制御する
タイトル(掲載誌)Journal of pharmacological sciences
一般注記This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Regulation of intestinal secretion is important for body fluid homeostasis. We investigated the role of three MAP kinases (MAPKs) as negative regulators in muscarinic cholinoceptor (mAChR)-mediated intestinal secretion in mice. Electrophysiological analyses revealed that mAChR stimulation enhanced intestinal chloride secretion, which was further augmented by the inhibition of JNK but not by that of ERK or p38 with specific inhibitors SP600125, U0126 or SB203580, respectively. Immunoblot analyses in colonic mucosa showed that mAChR stimulation increased MAPKs phosphorylation that was suppressed by the specific inhibitor for each MAPK. This suggests that JNK is a major negative regulator in mAChR-induced intestinal secretion.
identifier:PMID:25704031
開始ページ : 150
終了ページ : 153
DOIinfo:doi/10.1016/j.jphs.2014.10.001
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