Muscarinic cholinoceptor-mediated activation of JNK negatively regulates intestinal secretion in mice

Persistent ID (NDL): info:ndljp/pid/11092134

Material type: 博士論文

Author: Md. Tariqul, Islam

Publisher: -

Publication date: 2015-01

Material Format: Digital

Capacity, size, etc.: -

Name of awarding university/degree: 旭川医科大学,博士（医学）

View All

Notes on use at the National Diet Library

本資料は、掲載誌(URI)等のリンク先にある学位授与機関のWebサイトやCiNii Dissertationsから、本文を自由に閲覧できる場合があります。

Notes on use

Note (General)：: This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).Regulation of intestinal secretion is...

Search by Bookstore

Read this material in an accessible format.

View materials in accessible formats for people with print disabilities (1Type)

Search by Bookstore

Read in Disability Resources

Other Services
- テキストデータ check it on 国立国会図書館デジタルコレクション

Bibliographic Record

You can check the details of this material, its authority (keywords that refer to materials on the same subject, author's name, etc.), etc.

Digital

Material Type: 博士論文
ISSN: 1347-8613
Title: Muscarinic cholinoceptor-mediated activation of JNK negatively regulates intestinal secretion in mice
Volume: 127 1
Author/Editor: Md. Tariqul, Islam
Publication Date: 2015-01
Publication Date (W3CDTF): 2015-01
Alternative Title: ムスカリン性アセチルコリン受容体によるJNKの活性化はマウス腸管における分泌を負に制御する
Periodical title: Journal of pharmacological sciences
Degree grantor/type: 旭川医科大学
Date Granted: 2018-03-23
Date Granted (W3CDTF): 2018-03-23
Dissertation Number: 甲第524号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第524号
Text Language Code: eng
Subject Heading: Intestinal secretion
MAP kinase
mAChR
Note (General): This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Regulation of intestinal secretion is important for body fluid homeostasis. We investigated the role of three MAP kinases (MAPKs) as negative regulators in muscarinic cholinoceptor (mAChR)-mediated intestinal secretion in mice. Electrophysiological analyses revealed that mAChR stimulation enhanced intestinal chloride secretion, which was further augmented by the inhibition of JNK but not by that of ERK or p38 with specific inhibitors SP600125, U0126 or SB203580, respectively. Immunoblot analyses in colonic mucosa showed that mAChR stimulation increased MAPKs phosphorylation that was suppressed by the specific inhibitor for each MAPK. This suggests that JNK is a major negative regulator in mAChR-induced intestinal secretion.
identifier:PMID：25704031
開始ページ : 150
終了ページ : 153
DOI: info:doi/10.1016/j.jphs.2014.10.001
https://doi.org/info:doi/10.1016/j.jphs.2014.10.001
Persistent ID (NDL): info:ndljp/pid/11092134
https://dl.ndl.go.jp/pid/11092134
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2018-05-04T12:13:37+09:00
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://amcor.asahikawa-med.ac.jp/modules/xoonips/detail.php?id=20180323_K524
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp