並列タイトル等Effect of a neural relay on liver regeneration in mice : activation of serotonin release from the gastrointestinal tract
肝障害時の神経ネットワークを介した、消化管からのセロトニン分泌による肝再生への寄与の検証
一般注記The development of therapeutic options to promote hepatic regeneration following severe liver injury is essential. While humoral factors have been reported as mechanisms of liver regeneration, the contributions of inter-organ communication to liver regeneration have not been reported. In this study, we examined the effect of a neural relay on liver regeneration via activation of serotonin release from the gastrointestinal tract. Our results demonstrated that the afferent visceral nerve from the liver activates the efferent vagus nerve from the brain, leading to activation of serotonin release from the gastrointestinal tract and contributing to liver regeneration. While it is difficult to apply these results directly to human health, we believe that this study may represent a step forwards developing essential therapeutics to promote liver regeneration.
学位の種類: 博士（医学）. 報告番号: 甲第4387号. 学位記番号: 新大院博（医）甲第786号. 学位授与年月日: 平成30年3月23日
FEBS Open Bio. 2018. 8(3), 449-460.
新大院博（医）甲第786号
元資料の権利情報 : (C) 2018 The Authors. Published by FEBS Press and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
開始ページ : 1
終了ページ : 33
DOIinfo:doi/10.1002/2211-5463.12382
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受理日（W3CDTF）2018-08-03T23:36:01+09:00
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