Effect of a neural relay on liver regeneration in mice : activation of serotonin release from the gastrointestinal tract

• Material Type: 博士論文
• Title: Effect of a neural relay on liver regeneration in mice : activation of serotonin release from the gastrointestinal tract
• Author/Editor: Inoue, Ryosuke
• Publication, Distribution, etc.: 新潟大学
• Publication Date: 2018-03-23
• Publication Date (W3CDTF): 2018-03-23
• Alternative Title: Effect of a neural relay on liver regeneration in mice : activation of serotonin release from the gastrointestinal tract; 肝障害時の神経ネットワークを介した、消化管からのセロトニン分泌による肝再生への寄与の検証
• Degree grantor/type: 新潟大学
• Date Granted: 2018-03-23
• Date Granted (W3CDTF): 2018-03-23
• Dissertation Number: 甲第4387号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第4387号
• Text Language Code: eng
• Subject Heading: neural relay; liver regeneration; gastrointestinal tract; hormone; serotonin
• Note (General): The development of therapeutic options to promote hepatic regeneration following severe liver injury is essential. While humoral factors have been reported as mechanisms of liver regeneration, the contributions of inter-organ communication to liver regeneration have not been reported. In this study, we examined the effect of a neural relay on liver regeneration via activation of serotonin release from the gastrointestinal tract. Our results demonstrated that the afferent visceral nerve from the liver activates the efferent vagus nerve from the brain, leading to activation of serotonin release from the gastrointestinal tract and contributing to liver regeneration. While it is difficult to apply these results directly to human health, we believe that this study may represent a step forwards developing essential therapeutics to promote liver regeneration.; 学位の種類: 博士（医学）. 報告番号: 甲第4387号. 学位記番号: 新大院博（医）甲第786号. 学位授与年月日: 平成30年3月23日; FEBS Open Bio. 2018. 8(3), 449-460.; 新大院博（医）甲第786号; 元資料の権利情報 : (C) 2018 The Authors. Published by FEBS Press and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.; 開始ページ : 1; 終了ページ : 33
• DOI: info:doi/10.1002/2211-5463.12382; https://doi.org/info:doi/10.1002/2211-5463.12382
• Persistent ID (NDL): info:ndljp/pid/11123975; https://dl.ndl.go.jp/pid/11123975
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2018-08-03T23:36:01+09:00
• Date Created (W3CDTF): 2019-08-05
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10191/50422
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp