並列タイトル等The novel preventive effect of Daikenchuto (TJ-100), a Japanese herbal drug, against neonatal necrotizing enterocolitis (NEC) model in rats.
タイトル（掲載誌）Pediatric Surgery International
学位博士(医学)
Doctor of Philosophy in Medical Science
一般注記博士論文全文, 最終試験結果の要旨, 論文審査の要旨, 博士論文要旨
Purpose: Necrotizing enterocolitis (NEC) is a devastating gastrointestinal disease of premature infants. Daikenchuto, a Japanese herbal drug has several effects on the digestive system, so we investigated its preventive effects in a rat model of NEC.Methods: NEC was induced in newborn rats via asphyxia (100% N2 for 90 s; every 4 h) + LPS (4 mg/kg/day [administered orally on Days 0 and 1]). The effects of Daikenchuto were evaluated in 4 groups (control: 0 g/kg/day, I: 0.3 g/kg/day, II: 0.6 g/kg/day, III: 1.0 g/kg/day). Daikenchuto was administered into the stomach through a microcatheter. The incidence and severity of NEC were pathologically assessed using the NEC grade in accordance with Dovorak’s previous report. Cell positivity for inflammatory cytokine (IL-6) was also evaluated.Results: Daikenchuto reduced the incidence of NEC in control, Groups I, II, and III to 68.7%, 30.0%, 30.7%, and 13.3%, respectively. High dose Daikenchuto significantly improved the incidence of NEC, and the rate of IL-6 positive cells in group III was significantly lower than in the control group (p=0.04).Conclusion: We evaluated the effect of Daikenchuto against NEC and found that it reduced the incidence rate of NEC due to a decrease in the IL-6 production.
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受理日（W3CDTF）2018-11-05T10:48:21+09:00
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