新生児壊死性腸炎ラットモデルに対する大建中湯の予防効果

• Material Type: 博士論文
• Title: 新生児壊死性腸炎ラットモデルに対する大建中湯の予防効果
• Volume: 33 10
• Author/Editor: 新山, 新
• Author Heading: 新山, 新
• Publication, Distribution, etc.: Springer
• Publication Date: 2017-10; 33 10
• Publication Date (W3CDTF): 2017-10
• Alternative Title: The novel preventive effect of Daikenchuto (TJ-100), a Japanese herbal drug, against neonatal necrotizing enterocolitis (NEC) model in rats.
• Periodical title: Pediatric Surgery International
• Degree grantor/type: 鹿児島大学
• Date Granted: 2017-12-22
• Date Granted (W3CDTF): 2017-12-22
• Dissertation Number: 甲総研第442号
• Degree Type: 博士(医学); Doctor of Philosophy in Medical Science
• Conferring No. (Dissertation): 甲総研第442号
• Text Language Code: eng
• Subject Heading: necrotizing enterocolitis; rat model; Daikenchuto; NEC grade; IL-6
• NDC: 493
• Target Audience: 一般
• Note (General): 博士論文全文, 最終試験結果の要旨, 論文審査の要旨, 博士論文要旨; Purpose: Necrotizing enterocolitis (NEC) is a devastating gastrointestinal disease of premature infants. Daikenchuto, a Japanese herbal drug has several effects on the digestive system, so we investigated its preventive effects in a rat model of NEC.Methods: NEC was induced in newborn rats via asphyxia (100% N2 for 90 s; every 4 h) + LPS (4 mg/kg/day [administered orally on Days 0 and 1]). The effects of Daikenchuto were evaluated in 4 groups (control: 0 g/kg/day, I: 0.3 g/kg/day, II: 0.6 g/kg/day, III: 1.0 g/kg/day). Daikenchuto was administered into the stomach through a microcatheter. The incidence and severity of NEC were pathologically assessed using the NEC grade in accordance with Dovorak’s previous report. Cell positivity for inflammatory cytokine (IL-6) was also evaluated.Results: Daikenchuto reduced the incidence of NEC in control, Groups I, II, and III to 68.7%, 30.0%, 30.7%, and 13.3%, respectively. High dose Daikenchuto significantly improved the incidence of NEC, and the rate of IL-6 positive cells in group III was significantly lower than in the control group (p=0.04).Conclusion: We evaluated the effect of Daikenchuto against NEC and found that it reduced the incidence rate of NEC due to a decrease in the IL-6 production.
• Persistent ID (NDL): info:ndljp/pid/11178399; https://dl.ndl.go.jp/pid/11178399
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2018-11-05T10:48:21+09:00
• Date Created (W3CDTF): 2018-01-15
• Format (IMT): PDF; text/html; application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Original Material (URI): https://link.springer.com/article/10.1007%2Fs00383-017-4145-9
• Periodical Title (URI): http://hdl.handle.net/10232/00029969
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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