Serum exosomal microRNA?122 and microRNA?21 as predictive biomarkers in transarterial chemoembolization?treated hepatocellular carcinoma patients

• 資料種別: 博士論文
• ISSN: 1792-1074
• タイトル: Serum exosomal microRNA?122 and microRNA?21 as predictive biomarkers in transarterial chemoembolization?treated hepatocellular carcinoma patients
• 巻次・部編番号: 16 3
• 著者・編者: 末廣, 智之
• 著者標目: 末廣, 智之
• 出版事項: Spandidos Publications
• 出版年月日等: 2018-09-05
• 出版年（W3CDTF）: 2018-09-05
• 並列タイトル等: 経動脈的化学塞栓術を行った肝細胞癌患者のバイオマーカーとしての血清中のexosomal microRNA-122およびmicroRNA-21の意義
• タイトル（掲載誌）: Oncology Letters
• 授与機関名: Nagasaki University (長崎大学)
• 授与年月日: 2018-09-05
• 授与年月日（W3CDTF）: 2018-09-05
• 報告番号: 甲医歯薬第1091号
• 学位: 博士(医学)
• 博論授与番号: 甲医歯薬第1091号
• 本文の言語コード: eng
• 件名標目: carcinoma; hepatocellular; chemoembolization; therapeutic; exosome; microRNA
• 対象利用者: 一般
• 一般注記: Exosomal microRNAs (miRNAs) have been investigated as potential novel biomarkers, and miR?122 and miR?21 were shown to be important in hepatocellular carcinoma (HCC). We analyzed the importance of serum exosomal miRNA expression levels in HCC patients that underwent transarterial chemoembolization (TACE). Seventy?five HCC patients who underwent TACE as the initial treatment in Nagasaki University Hospital were enrolled. Exosomal miRNAs were isolated from serum samples collected before and after TACE. Exosomal miR?122 expression levels significantly decreased after TACE (P=0.012), while the exosomal miR?21 expression levels did not significantly change. The expression levels of exosomal miR?122 before TACE were shown to correlate significantly with aspartate aminotransferase (r=0.31, P=0.004) and alanine aminotransferase (r=0.33, P=0.003) levels, tumor diameter (r=0.29, P=0.010) and Child?Pugh score (r=?0.28, P=0.013). The median survival time for all patients was 47 months, and neither of the investigated exosomal miRNAs were shown to be independent factors associated with the disease?specific survival. According to the median relative expression of miR?122 after TACE/before TACE (miR?122 ratio) in liver cirrhosis patients (n=57), the patients with a higher miR?122 ratio had significantly longer disease?specific survival, compared with that of the patients with the lower miR?122 ratio (P=0.0461). Multivariate Cox proportional hazards regression analysis of clinical parameters revealed that a lower exosomal miR?122 ratio (HR 2.720; 95% confidence interval, 1.035?8.022; P=0.042) is associated with the disease?specific survival. Taken together, our results demonstrate that the exosomal miR?122 level alterations may represent a predictive biomarker in HCC patients with liver cirrhosis treated with TACE.; 長崎大学学位論文 学位記番号:博(医歯薬)甲第1091号 学位授与年月日:平成30年9月5日; Author: Tomoyuki Suehiro, Hisamitsu Miyaaki, Yasuko Kanda, Hidetaka Shibata, Takuya Honda, Eisuke Ozawa, Satoshi Miuma, Naota Taura, Kazuhiko Nakao; Citation: Oncology Letters, 16(3), pp.3267-3273; 2018; Nagasaki University (長崎大学), 博士(医学) (2018-09-05)
• DOI: info:doi/10.3892/ol.2018.8991; https://doi.org/info:doi/10.3892/ol.2018.8991
• 国立国会図書館永続的識別子: info:ndljp/pid/11217005; https://dl.ndl.go.jp/pid/11217005
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2019-01-04T08:16:43+09:00
• 作成日（W3CDTF）: 2020-12-18
• 記録形式（IMT）: PDF
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://hdl.handle.net/10069/38578; https://nagasaki-u.repo.nii.ac.jp/records/1315
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

目次

2021-03-07 再収集