Serum exosomal microRNA?122 and microRNA?21 as predictive biomarkers in transarterial chemoembolization?treated hepatocellular carcinoma patients

• Material Type: 博士論文
• ISSN: 1792-1074
• Title: Serum exosomal microRNA?122 and microRNA?21 as predictive biomarkers in transarterial chemoembolization?treated hepatocellular carcinoma patients
• Volume: 16 3
• Author/Editor: 末廣, 智之
• Author Heading: 末廣, 智之
• Publication, Distribution, etc.: Spandidos Publications
• Publication Date: 2018-09-05
• Publication Date (W3CDTF): 2018-09-05
• Alternative Title: 経動脈的化学塞栓術を行った肝細胞癌患者のバイオマーカーとしての血清中のexosomal microRNA-122およびmicroRNA-21の意義
• Periodical title: Oncology Letters
• Degree grantor/type: Nagasaki University (長崎大学)
• Date Granted: 2018-09-05
• Date Granted (W3CDTF): 2018-09-05
• Dissertation Number: 甲医歯薬第1091号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲医歯薬第1091号
• Text Language Code: eng
• Subject Heading: carcinoma; hepatocellular; chemoembolization; therapeutic; exosome; microRNA
• Target Audience: 一般
• Note (General): Exosomal microRNAs (miRNAs) have been investigated as potential novel biomarkers, and miR?122 and miR?21 were shown to be important in hepatocellular carcinoma (HCC). We analyzed the importance of serum exosomal miRNA expression levels in HCC patients that underwent transarterial chemoembolization (TACE). Seventy?five HCC patients who underwent TACE as the initial treatment in Nagasaki University Hospital were enrolled. Exosomal miRNAs were isolated from serum samples collected before and after TACE. Exosomal miR?122 expression levels significantly decreased after TACE (P=0.012), while the exosomal miR?21 expression levels did not significantly change. The expression levels of exosomal miR?122 before TACE were shown to correlate significantly with aspartate aminotransferase (r=0.31, P=0.004) and alanine aminotransferase (r=0.33, P=0.003) levels, tumor diameter (r=0.29, P=0.010) and Child?Pugh score (r=?0.28, P=0.013). The median survival time for all patients was 47 months, and neither of the investigated exosomal miRNAs were shown to be independent factors associated with the disease?specific survival. According to the median relative expression of miR?122 after TACE/before TACE (miR?122 ratio) in liver cirrhosis patients (n=57), the patients with a higher miR?122 ratio had significantly longer disease?specific survival, compared with that of the patients with the lower miR?122 ratio (P=0.0461). Multivariate Cox proportional hazards regression analysis of clinical parameters revealed that a lower exosomal miR?122 ratio (HR 2.720; 95% confidence interval, 1.035?8.022; P=0.042) is associated with the disease?specific survival. Taken together, our results demonstrate that the exosomal miR?122 level alterations may represent a predictive biomarker in HCC patients with liver cirrhosis treated with TACE.; 長崎大学学位論文 学位記番号:博(医歯薬)甲第1091号 学位授与年月日:平成30年9月5日; Author: Tomoyuki Suehiro, Hisamitsu Miyaaki, Yasuko Kanda, Hidetaka Shibata, Takuya Honda, Eisuke Ozawa, Satoshi Miuma, Naota Taura, Kazuhiko Nakao; Citation: Oncology Letters, 16(3), pp.3267-3273; 2018; Nagasaki University (長崎大学), 博士(医学) (2018-09-05)
• DOI: info:doi/10.3892/ol.2018.8991; https://doi.org/info:doi/10.3892/ol.2018.8991
• Persistent ID (NDL): info:ndljp/pid/11217005; https://dl.ndl.go.jp/pid/11217005
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2019-01-04T08:16:43+09:00
• Date Created (W3CDTF): 2020-12-18
• Format (IMT): PDF
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10069/38578; https://nagasaki-u.repo.nii.ac.jp/records/1315
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2021-03-07 再収集