Nab-paclitaxel interrupts cancer-stromal interaction through C-X-C motif chemokine 10-mediated interleukin-6 downregulation in vitro 8

• 資料種別: 博士論文
• ISSN: 1349-7006
• タイトル: Nab-paclitaxel interrupts cancer-stromal interaction through C-X-C motif chemokine 10-mediated interleukin-6 downregulation in vitro
• 巻次・部編番号: 109 8
• 著者・編者: Feng, Rui; Morine, Yuji; Ikemoto, Tetsuya; Imura, Satoru; Iwahashi, Shuichi; Saitou, Yu; Shimada, Mitsuo
• 著者標目: Feng, Rui; Morine, Yuji; Ikemoto, Tetsuya; Imura, Satoru; Iwahashi, Shuichi; Saitou, Yu; Shimada, Mitsuo
• 出版事項: Wiley|Japanese Cancer Association
• 出版年月日等: 2018-06-14
• 出版年（W3CDTF）: 2018-06-14
• 並列タイトル等: Nab-paclitaxelはin vitroでC-X-C motif chemokine 10を介したinterleukin-6制御により癌－間質相互作用を抑制する
• タイトル（掲載誌）: Cancer Science
• 授与機関名: 徳島大学
• 授与年月日: 2018-10-25
• 授与年月日（W3CDTF）: 2018-10-25
• 報告番号: 甲第3242号
• 学位: 博士（医学）
• 博論授与番号: 甲第3242号
• 本文の言語コード: eng
• 件名標目: 130nm albumin-bound paclitaxel; cancer-associated fibroblast; C-X-C motif chemokine 10; epithelial-mesenchymal transition; pancreatic neoplasms; chemokine CXCL10
• 対象利用者: 一般
• 一般注記: Cancer‐associated fibroblasts (CAF), derived from stroma of cancer tissues, interact with cancer cells and play an important role in cancer initiation, growth, and metastasis. Nab‐paclitaxel (nab‐PTX) is a 130 nm albumin‐binding paclitaxel and recommended for many types of cancer chemotherapy. The nab‐PTX stromal‐disrupting effect during pancreatic cancer treatment has been reported. The aim of the present study was to determine the role of nab‐PTX in cancer cells and CAF interaction. Cancer cells (MIA PaCa‐2 and Panc‐1) were cocultured with CAF or treated with CAF conditioned medium, after which their migration and invasion ability, epithelial‐mesenchymal transition (EMT)‐related marker expression and C‐X‐C motif chemokine 10 (CXCL10) expression and secretion were detected. Nab‐PTX treatment was carried out during the coculture system or during preparation of CAF conditioned medium. Then cancer cell migration and invasion ability, EMT‐related marker expression, CXCL10 expression and secretion, and interleukin‐6 (IL‐6) expression and secretion by CAF were checked After coculture with CAF, migration and invasion ability of cancer cells increased. CAF also downregulated E‐cadherin and upregulated N‐cadherin and vimentin expression in cancer cells. During coculture or stimulation with cancer cell‐cultured medium, CAF significantly increased IL‐6 expression and secretion. However, nab‐PTX in the coculture system canceled CAF‐induced migration and invasion promotion and EMT-related gene changes. Moreover, nab‐PTX increased CXCL10 expression of cancer cells which blocked CAF IL‐6 expression and secretion. Nab‐PTX treatment could increase CXCL10 expression of cancer cells which blocks CAF cancer cell migration and invasion‐promoting effect by inhibiting IL‐6 expression.
• DOI: info:doi/10.1111/cas.13694; https://doi.org/info:doi/10.1111/cas.13694
• 国立国会図書館永続的識別子: info:ndljp/pid/11239182; https://dl.ndl.go.jp/pid/11239182
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2019-02-03T04:35:56+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://repo.lib.tokushima-u.ac.jp/112899
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

目次

2023-09-07 再収集