Nab-paclitaxel interrupts cancer-stromal interaction through C-X-C motif chemokine 10-mediated interleukin-6 downregulation in vitro

• Material Type: 博士論文
• ISSN: 1349-7006
• Title: Nab-paclitaxel interrupts cancer-stromal interaction through C-X-C motif chemokine 10-mediated interleukin-6 downregulation in vitro
• Volume: 109 8
• Author/Editor: Feng, Rui; Morine, Yuji; Ikemoto, Tetsuya; Imura, Satoru; Iwahashi, Shuichi; Saitou, Yu; Shimada, Mitsuo
• Author Heading: Feng, Rui; Morine, Yuji; Ikemoto, Tetsuya; Imura, Satoru; Iwahashi, Shuichi; Saitou, Yu; Shimada, Mitsuo
• Publication, Distribution, etc.: Wiley|Japanese Cancer Association
• Publication Date: 2018-06-14
• Publication Date (W3CDTF): 2018-06-14
• Alternative Title: Nab-paclitaxelはin vitroでC-X-C motif chemokine 10を介したinterleukin-6制御により癌－間質相互作用を抑制する
• Periodical title: Cancer Science
• Degree grantor/type: 徳島大学
• Date Granted: 2018-10-25
• Date Granted (W3CDTF): 2018-10-25
• Dissertation Number: 甲第3242号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第3242号
• Text Language Code: eng
• Subject Heading: 130nm albumin-bound paclitaxel; cancer-associated fibroblast; C-X-C motif chemokine 10; epithelial-mesenchymal transition; pancreatic neoplasms; chemokine CXCL10
• Target Audience: 一般
• Note (General): Cancer‐associated fibroblasts (CAF), derived from stroma of cancer tissues, interact with cancer cells and play an important role in cancer initiation, growth, and metastasis. Nab‐paclitaxel (nab‐PTX) is a 130 nm albumin‐binding paclitaxel and recommended for many types of cancer chemotherapy. The nab‐PTX stromal‐disrupting effect during pancreatic cancer treatment has been reported. The aim of the present study was to determine the role of nab‐PTX in cancer cells and CAF interaction. Cancer cells (MIA PaCa‐2 and Panc‐1) were cocultured with CAF or treated with CAF conditioned medium, after which their migration and invasion ability, epithelial‐mesenchymal transition (EMT)‐related marker expression and C‐X‐C motif chemokine 10 (CXCL10) expression and secretion were detected. Nab‐PTX treatment was carried out during the coculture system or during preparation of CAF conditioned medium. Then cancer cell migration and invasion ability, EMT‐related marker expression, CXCL10 expression and secretion, and interleukin‐6 (IL‐6) expression and secretion by CAF were checked After coculture with CAF, migration and invasion ability of cancer cells increased. CAF also downregulated E‐cadherin and upregulated N‐cadherin and vimentin expression in cancer cells. During coculture or stimulation with cancer cell‐cultured medium, CAF significantly increased IL‐6 expression and secretion. However, nab‐PTX in the coculture system canceled CAF‐induced migration and invasion promotion and EMT-related gene changes. Moreover, nab‐PTX increased CXCL10 expression of cancer cells which blocked CAF IL‐6 expression and secretion. Nab‐PTX treatment could increase CXCL10 expression of cancer cells which blocks CAF cancer cell migration and invasion‐promoting effect by inhibiting IL‐6 expression.
• DOI: info:doi/10.1111/cas.13694; https://doi.org/info:doi/10.1111/cas.13694
• Persistent ID (NDL): info:ndljp/pid/11239182; https://dl.ndl.go.jp/pid/11239182
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2019-02-03T04:35:56+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/112899
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2023-09-07 再収集