Development of the novel oligonucleotides for the functional regulation of RISC by promotional release of microRNA from RISC

• 資料種別: 博士論文
• タイトル: Development of the novel oligonucleotides for the functional regulation of RISC by promotional release of microRNA from RISC
• 著者・編者: Ariyoshi, Jumpei
• 出版年月日等: 2017-03-24
• 出版年（W3CDTF）: 2017-03-24
• 並列タイトル等: RISCのmicroRNAの保持機構に着目した遺伝子制御分子の開発
• 授与機関名: 京都工芸繊維大学
• 授与年月日: 2017-03-24
• 授与年月日（W3CDTF）: 2017-03-24
• 報告番号: 甲第821号
• 学位: 博士（学術）
• 博論授与番号: 甲第821号
• 本文の言語コード: eng
• 件名標目: microRNA; RNA-induced silencing complex; RISC; Non-coding RNA; Anti-miRNA oligonucleotide; AMO
• 一般注記: MicroRNAs (miRNAs) are short non-coding RNAs, which play important roles in many biological functions in multicellular organisms. In recent reports, aberrant expressions of miRNAs in several pathological processes, including those in cancers, have been described. Therefore, miRNAs have been considered as promising therapeutic targets. The miRNA duplex associates with the Argonaute protein (Ago) to form ribonucleoprotein complexes called RNA-induced silencing complex (RISC). MiRNA is a core component of RISC and is an essential to RISC for recognizing target mRNA. Thereby, it is expected that development of the method to promote the release of miRNA from RISC would be an effective approach for inhibition of RISC activity. This study presents development of the novel anti-miRNA oligonucleotides (AMOs) to promote the release of miRNA from RISC.
• 国立国会図書館永続的識別子: info:ndljp/pid/11239196; https://dl.ndl.go.jp/pid/11239196
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2019-02-03T04:35:56+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://hdl.handle.net/10212/2379
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp