Development of the novel oligonucleotides for the functional regulation of RISC by promotional release of microRNA from RISC

Persistent ID (NDL): info:ndljp/pid/11239196

Material type: 博士論文

Author: Ariyoshi, Jumpei

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Publication date: 2017-03-24

Material Format: Digital

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Name of awarding university/degree: 京都工芸繊維大学,博士（学術）

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Note (General)：: MicroRNAs (miRNAs) are short non-coding RNAs, which play important roles in many biological functions in multicellular organisms. In recent reports, a...

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Material Type: 博士論文
Title: Development of the novel oligonucleotides for the functional regulation of RISC by promotional release of microRNA from RISC
Author/Editor: Ariyoshi, Jumpei
Publication Date: 2017-03-24
Publication Date (W3CDTF): 2017-03-24
Alternative Title: RISCのmicroRNAの保持機構に着目した遺伝子制御分子の開発
Degree grantor/type: 京都工芸繊維大学
Date Granted: 2017-03-24
Date Granted (W3CDTF): 2017-03-24
Dissertation Number: 甲第821号
Degree Type: 博士（学術）
Conferring No. (Dissertation): 甲第821号
Text Language Code: eng
Subject Heading: microRNA
RNA-induced silencing complex
RISC
Non-coding RNA
Anti-miRNA oligonucleotide
AMO
Note (General): MicroRNAs (miRNAs) are short non-coding RNAs, which play important roles in many biological functions in multicellular organisms. In recent reports, aberrant expressions of miRNAs in several pathological processes, including those in cancers, have been described. Therefore, miRNAs have been considered as promising therapeutic targets. The miRNA duplex associates with the Argonaute protein (Ago) to form ribonucleoprotein complexes called RNA-induced silencing complex (RISC). MiRNA is a core component of RISC and is an essential to RISC for recognizing target mRNA. Thereby, it is expected that development of the method to promote the release of miRNA from RISC would be an effective approach for inhibition of RISC activity. This study presents development of the novel anti-miRNA oligonucleotides (AMOs) to promote the release of miRNA from RISC.
Persistent ID (NDL): info:ndljp/pid/11239196
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Date Accepted (W3CDTF): 2019-02-03T04:35:56+09:00
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Periodical Title (URI): http://hdl.handle.net/10212/2379
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