Th17 cells differentiated with mycelial membranes of Candida albicans prevent oral candidiasis

• 資料種別: 博士論文
• タイトル: Th17 cells differentiated with mycelial membranes of Candida albicans prevent oral candidiasis
• 著者・編者: Sonoko, Tasaki; Tamaki, Cho; Jun-ichi, Nagao; Shojiro, Ikezaki; Yuka, Narita; Ken-ichi, Arita-Morioka; Kanae, Yasumatsu; Keita, Toyoda; Hiroshi, Kojima; Yoshihiko, Tanaka
• 著者標目: Sonoko, Tasaki; Tamaki, Cho; Jun-ichi, Nagao; Shojiro, Ikezaki; Yuka, Narita; Ken-ichi, Arita-Morioka; Kanae, Yasumatsu; Keita, Toyoda; Hiroshi, Kojima; Yoshihiko, Tanaka
• 出版年月日等: 2018-03-29
• 出版年（W3CDTF）: 2018-03-29
• 並列タイトル等: Th17 cells differentiated with mycelial membranes of Candida albicans prevent oral candidiasis
• 授与機関名: 福岡歯科大学
• 授与年月日: 2018-03-29
• 授与年月日（W3CDTF）: 2018-03-29
• 報告番号: 甲第298号
• 学位: 博士（歯学）
• 博論授与番号: 甲第298号
• 本文の言語コード: eng
• 件名標目: Candida albicans; mycelial membranes; Th17; oral candidiasis; adoptive transfer
• 対象利用者: 一般
• 一般注記: Candida albicans is a human commensal that causes opportunistic infections. Th17 cells provide resistance against mucosal infection with C. albicans; however, the T cell antigens remain little known. Our final goal is to find effective T cell antigens of C. albicans that are responsible for immunotherapy against candidiasis. Here, we prepared fractions including cytosol, membrane and cell wall from yeast and mycelial cells. Proteins derived from a membrane fraction of mycelial cells effectively induced differentiation of CD4+ T cells into IL-17A-producing Th17 cells. To confirm the immunological response in vivo of proteins from mycelial membrane, we performed adoptive transfer experiments using ex vivo stimulated CD4+ T cells from IL-17A-GFP reporter mice. Mycelial membrane-differentiated CD4+ Th17 cells adoptively transferred intravenously prevented oral candidiasis by oral infection of C. albicans, compared with control anti-CD3-stimulated CD4+ T cells. This was confirmed by the clinical score and the number of neutrophils on the infected tissues. These data suggest that effective T cell antigens against candidiasis could be present in the membrane protein fraction of mycelial cells. The design of novel vaccination strategies against candidiasis will be our next step.; OXFORD
• 国立国会図書館永続的識別子: info:ndljp/pid/11246154; https://dl.ndl.go.jp/pid/11246154
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2019-03-03T03:58:25+09:00
• 作成日（W3CDTF）: 2019-02-06
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 原資料（URI）: https://doi.org/10.1093/femsyr/foy018
• 掲載誌（URI）: https://fdc.repo.nii.ac.jp/records/95
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

目次

2023-08-05 再収集

2023-08-05 再収集

2023-08-05 再収集

2023-12-06 再収集

2023-12-06 再収集