Th17 cells differentiated with mycelial membranes of Candida albicans prevent oral candidiasis

• Material Type: 博士論文
• Title: Th17 cells differentiated with mycelial membranes of Candida albicans prevent oral candidiasis
• Author/Editor: Sonoko, Tasaki; Tamaki, Cho; Jun-ichi, Nagao; Shojiro, Ikezaki; Yuka, Narita; Ken-ichi, Arita-Morioka; Kanae, Yasumatsu; Keita, Toyoda; Hiroshi, Kojima; Yoshihiko, Tanaka
• Author Heading: Sonoko, Tasaki; Tamaki, Cho; Jun-ichi, Nagao; Shojiro, Ikezaki; Yuka, Narita; Ken-ichi, Arita-Morioka; Kanae, Yasumatsu; Keita, Toyoda; Hiroshi, Kojima; Yoshihiko, Tanaka
• Publication Date: 2018-03-29
• Publication Date (W3CDTF): 2018-03-29
• Alternative Title: Th17 cells differentiated with mycelial membranes of Candida albicans prevent oral candidiasis
• Degree grantor/type: 福岡歯科大学
• Date Granted: 2018-03-29
• Date Granted (W3CDTF): 2018-03-29
• Dissertation Number: 甲第298号
• Degree Type: 博士（歯学）
• Conferring No. (Dissertation): 甲第298号
• Text Language Code: eng
• Subject Heading: Candida albicans; mycelial membranes; Th17; oral candidiasis; adoptive transfer
• Target Audience: 一般
• Note (General): Candida albicans is a human commensal that causes opportunistic infections. Th17 cells provide resistance against mucosal infection with C. albicans; however, the T cell antigens remain little known. Our final goal is to find effective T cell antigens of C. albicans that are responsible for immunotherapy against candidiasis. Here, we prepared fractions including cytosol, membrane and cell wall from yeast and mycelial cells. Proteins derived from a membrane fraction of mycelial cells effectively induced differentiation of CD4+ T cells into IL-17A-producing Th17 cells. To confirm the immunological response in vivo of proteins from mycelial membrane, we performed adoptive transfer experiments using ex vivo stimulated CD4+ T cells from IL-17A-GFP reporter mice. Mycelial membrane-differentiated CD4+ Th17 cells adoptively transferred intravenously prevented oral candidiasis by oral infection of C. albicans, compared with control anti-CD3-stimulated CD4+ T cells. This was confirmed by the clinical score and the number of neutrophils on the infected tissues. These data suggest that effective T cell antigens against candidiasis could be present in the membrane protein fraction of mycelial cells. The design of novel vaccination strategies against candidiasis will be our next step.; OXFORD
• Persistent ID (NDL): info:ndljp/pid/11246154; https://dl.ndl.go.jp/pid/11246154
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2019-03-03T03:58:25+09:00
• Date Created (W3CDTF): 2019-02-06
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Original Material (URI): https://doi.org/10.1093/femsyr/foy018
• Periodical Title (URI): https://fdc.repo.nii.ac.jp/records/95
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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