並列タイトル等Thyroid Function of Asphyxiated Newborns who Received Hypothermia Therapy
低体温療法を施行した新生児仮死児の甲状腺機能
一般注記Background: Thyroid function of asphyxiated newborns who received hypothermia therapy and its relation to neurological outcome are not well described. Methods: This is a prospective study measuring thyroid function of 12 asphyxiated newborns who received hypothermia therapy. We measured serum thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) levels on admission, 24, 72, and 96 hours after birth, and at discharge (17-54 days). Twelve newborns were divided into two groups based on the presence of brain injury on head magnetic resonance imaging findings (six in the abnormal imaging group and six in the normal imaging group) and their thyroid functions were compared between the twogroups. Results: Serum TSH levels were within a normal range. Serum FT3 and FT4 levels remained low at 24, 72, and 96 hours after birth, and returned to a normal range at discharge. There was no significant difference in serum TSH levels between the two groups. However, serum FT4 levels at 72 hours after birth, and serum FT3 and FT4 levels at 96 hours after birth were significantly lower in the abnormal imaging group than those in the normal imaging group (p=0.03, p=0.02, and p=0.01, respectively). Conclusion: These results suggest that asphyxiated newborns have transient low thyroid hormone levels at 24-96 hours after birth. Serum FT3 and FT4 levels between 72 and 96 hours after birth may predict brain injury of asphyxiated newborns.
学位の種類: 博士（医学）. 報告番号: 甲第4495号. 学位記番号: 新大院博（医）甲第832号. 学位授与年月日: 平成30年9月20日
Pediatrics International. 2018, 60(5), 433-437. First published: 20 February 2018.
新大院博（医）甲第832号
DOIinfo:doi/10.1111/ped.13534
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