Thyroid Function of Asphyxiated Newborns who Received Hypothermia Therapy

• Material Type: 博士論文
• Title: Thyroid Function of Asphyxiated Newborns who Received Hypothermia Therapy
• Author/Editor: Kobayashi, Akira
• Publication, Distribution, etc.: 新潟大学
• Publication Date: 2018-09-20
• Publication Date (W3CDTF): 2018-09-20
• Alternative Title: Thyroid Function of Asphyxiated Newborns who Received Hypothermia Therapy; 低体温療法を施行した新生児仮死児の甲状腺機能
• Degree grantor/type: 新潟大学
• Date Granted: 2018-09-20
• Date Granted (W3CDTF): 2018-09-20
• Dissertation Number: 甲第4495号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第4495号
• Text Language Code: eng
• Note (General): Background: Thyroid function of asphyxiated newborns who received hypothermia therapy and its relation to neurological outcome are not well described. Methods: This is a prospective study measuring thyroid function of 12 asphyxiated newborns who received hypothermia therapy. We measured serum thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) levels on admission, 24, 72, and 96 hours after birth, and at discharge (17-54 days). Twelve newborns were divided into two groups based on the presence of brain injury on head magnetic resonance imaging findings (six in the abnormal imaging group and six in the normal imaging group) and their thyroid functions were compared between the twogroups. Results: Serum TSH levels were within a normal range. Serum FT3 and FT4 levels remained low at 24, 72, and 96 hours after birth, and returned to a normal range at discharge. There was no significant difference in serum TSH levels between the two groups. However, serum FT4 levels at 72 hours after birth, and serum FT3 and FT4 levels at 96 hours after birth were significantly lower in the abnormal imaging group than those in the normal imaging group (p=0.03, p=0.02, and p=0.01, respectively). Conclusion: These results suggest that asphyxiated newborns have transient low thyroid hormone levels at 24-96 hours after birth. Serum FT3 and FT4 levels between 72 and 96 hours after birth may predict brain injury of asphyxiated newborns.; 学位の種類: 博士（医学）. 報告番号: 甲第4495号. 学位記番号: 新大院博（医）甲第832号. 学位授与年月日: 平成30年9月20日; Pediatrics International. 2018, 60(5), 433-437. First published: 20 February 2018.; 新大院博（医）甲第832号
• DOI: info:doi/10.1111/ped.13534; https://doi.org/info:doi/10.1111/ped.13534
• Persistent ID (NDL): info:ndljp/pid/11287808; https://dl.ndl.go.jp/pid/11287808
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2019-06-03T12:31:31+09:00
• Date Created (W3CDTF): 2019-09-10
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10191/50787
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp