Daily Coffee Intake Inhibits Pancreatic Beta Cell Damage and Nonalcoholic Steatohepatitis in a Mouse Model of Spontaneous Metabolic Syndrome, Tsumura-Suzuki Obese Diabetic Mice 4

• 資料種別: 博士論文
• ISSN: 1540-4196
• タイトル: Daily Coffee Intake Inhibits Pancreatic Beta Cell Damage and Nonalcoholic Steatohepatitis in a Mouse Model of Spontaneous Metabolic Syndrome, Tsumura-Suzuki Obese Diabetic Mice
• 巻次・部編番号: 15 4
• 著者・編者: Watanabe, Syunsuke; Takahashi, Tetsuyuki; Ogawa, Hirohisa; Uehara, Hisanori; Tsunematsu, Takaaki; Baba, Hayato; Morimoto, Yuki; Tsuneyama, Koichi
• 著者標目: Watanabe, Syunsuke; Takahashi, Tetsuyuki; Ogawa, Hirohisa; Uehara, Hisanori; Tsunematsu, Takaaki; Baba, Hayato; Morimoto, Yuki; Tsuneyama, Koichi
• 出版事項: Mary Ann Liebert, Inc.
• 出版年月日等: 2017-05-01
• 出版年（W3CDTF）: 2017-05-01
• 並列タイトル等: メタボリックシンドロームモデルマウス、TSODマウスにおいて、日常的なコーヒー摂取は膵臓β細胞へのダメージ及び非アルコール性脂肪肝を抑制する; EFFECTS OF COFFEE INTAKE ON METABOLIC SYNDROME
• タイトル（掲載誌）: Metabolic Syndrome and Related Disorders
• 授与機関名: 徳島大学
• 授与年月日: 2019-03-19
• 授与年月日（W3CDTF）: 2019-03-19
• 報告番号: 甲第3265号
• 学位: 博士（医学）
• 博論授与番号: 甲第3265号
• 本文の言語コード: eng
• 件名標目: animal model; beta cell failure; coffee intake; hepatocellular carcinoma; nonalcoholic steatohepatitis
• 対象利用者: 一般
• 一般注記: Background: Metabolic syndrome is one of the most important health issues worldwide. Obesity causes insulin resistance, hyperlipidemia, diabetes, and various diseases throughout the body. The liver phenotype, which is called nonalcoholic steatohepatitis (NASH), frequently progresses to hepatocellular carcinoma. We recently established a new animal model, Tsumura-Suzuki obese diabetic (TSOD) mice, which spontaneously exhibit obesity, diabetes, hyperlipidemia, and NASH with liver nodules.Methods: We examined the effects of coffee intake on various conditions of the metabolic syndrome using TSOD mice. The daily volume of coffee administered was limited so that it reflected the appropriate quantities consumed in humans. To clarify the effects of the specific components, animals were divided into two coffee-intake groups that included with and without caffeine.Results: Coffee intake did not significantly affect obesity and hyperlipidemia in TSOD mice. In contrast, coffee intake caused various degrees of improvement in the pancreatic beta cell damage and steatohepatitis with liver carcinogenesis. Most of the effects were believed to be caused by a synergistic effect of caffeine with other components such as polyphenols. However, the antifibrotic effects of coffee appeared to be due to the polyphenols rather than the caffeine.Conclusions: A daily habit of drinking coffee could possibly play a role in the prevention of metabolic syndrome.
• DOI: info:doi/10.1089/met.2016.0114; https://doi.org/info:doi/10.1089/met.2016.0114
• 国立国会図書館永続的識別子: info:ndljp/pid/11300294; https://dl.ndl.go.jp/pid/11300294
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2019-07-05T01:13:02+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://repo.lib.tokushima-u.ac.jp/113349
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp