Daily Coffee Intake Inhibits Pancreatic Beta Cell Damage and Nonalcoholic Steatohepatitis in a Mouse Model of Spontaneous Metabolic Syndrome, Tsumura-Suzuki Obese Diabetic Mice

• Material Type: 博士論文
• ISSN: 1540-4196
• Title: Daily Coffee Intake Inhibits Pancreatic Beta Cell Damage and Nonalcoholic Steatohepatitis in a Mouse Model of Spontaneous Metabolic Syndrome, Tsumura-Suzuki Obese Diabetic Mice
• Volume: 15 4
• Author/Editor: Watanabe, Syunsuke; Takahashi, Tetsuyuki; Ogawa, Hirohisa; Uehara, Hisanori; Tsunematsu, Takaaki; Baba, Hayato; Morimoto, Yuki; Tsuneyama, Koichi
• Author Heading: Watanabe, Syunsuke; Takahashi, Tetsuyuki; Ogawa, Hirohisa; Uehara, Hisanori; Tsunematsu, Takaaki; Baba, Hayato; Morimoto, Yuki; Tsuneyama, Koichi
• Publication, Distribution, etc.: Mary Ann Liebert, Inc.
• Publication Date: 2017-05-01
• Publication Date (W3CDTF): 2017-05-01
• Alternative Title: メタボリックシンドロームモデルマウス、TSODマウスにおいて、日常的なコーヒー摂取は膵臓β細胞へのダメージ及び非アルコール性脂肪肝を抑制する; EFFECTS OF COFFEE INTAKE ON METABOLIC SYNDROME
• Periodical title: Metabolic Syndrome and Related Disorders
• Degree grantor/type: 徳島大学
• Date Granted: 2019-03-19
• Date Granted (W3CDTF): 2019-03-19
• Dissertation Number: 甲第3265号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第3265号
• Text Language Code: eng
• Subject Heading: animal model; beta cell failure; coffee intake; hepatocellular carcinoma; nonalcoholic steatohepatitis
• Target Audience: 一般
• Note (General): Background: Metabolic syndrome is one of the most important health issues worldwide. Obesity causes insulin resistance, hyperlipidemia, diabetes, and various diseases throughout the body. The liver phenotype, which is called nonalcoholic steatohepatitis (NASH), frequently progresses to hepatocellular carcinoma. We recently established a new animal model, Tsumura-Suzuki obese diabetic (TSOD) mice, which spontaneously exhibit obesity, diabetes, hyperlipidemia, and NASH with liver nodules.Methods: We examined the effects of coffee intake on various conditions of the metabolic syndrome using TSOD mice. The daily volume of coffee administered was limited so that it reflected the appropriate quantities consumed in humans. To clarify the effects of the specific components, animals were divided into two coffee-intake groups that included with and without caffeine.Results: Coffee intake did not significantly affect obesity and hyperlipidemia in TSOD mice. In contrast, coffee intake caused various degrees of improvement in the pancreatic beta cell damage and steatohepatitis with liver carcinogenesis. Most of the effects were believed to be caused by a synergistic effect of caffeine with other components such as polyphenols. However, the antifibrotic effects of coffee appeared to be due to the polyphenols rather than the caffeine.Conclusions: A daily habit of drinking coffee could possibly play a role in the prevention of metabolic syndrome.
• DOI: info:doi/10.1089/met.2016.0114; https://doi.org/info:doi/10.1089/met.2016.0114
• Persistent ID (NDL): info:ndljp/pid/11300294; https://dl.ndl.go.jp/pid/11300294
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2019-07-05T01:13:02+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/113349
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp