Long-term polarization of alveolar macrophages to a profibrotic phenotype after inhalation exposure to multi-wall carbon nanotubes

• 資料種別: 博士論文
• ISSN: 1932-6203
• タイトル: Long-term polarization of alveolar macrophages to a profibrotic phenotype after inhalation exposure to multi-wall carbon nanotubes
• 巻次・部編番号: 13 10
• 著者・編者: Otsuka, Kunihiro; Yamada, Koichi; Taquahashi, Yuhji; Arakaki, Rieko; Ushio, Aya; Saito, Masako; Yamada, Akiko; Tsunematsu, Takaaki; Kudo, Yasusei; Kanno, Jun; Ishimaru, Naozumi
• 著者標目: Otsuka, Kunihiro; Yamada, Koichi; Taquahashi, Yuhji; Arakaki, Rieko; Ushio, Aya; Saito, Masako; Yamada, Akiko; Tsunematsu, Takaaki; Kudo, Yasusei; Kanno, Jun; Ishimaru, Naozumi
• 出版事項: PLOS
• 出版年月日等: 2018-10-29
• 出版年（W3CDTF）: 2018-10-29
• 並列タイトル等: 多層カーボンナノチューブの吸入曝露による線維化誘導型肺胞マクロファージへの長期変化; Effect of CNT exposure on alveolar macrophages
• タイトル（掲載誌）: PLOS ONE
• 授与機関名: 徳島大学
• 授与年月日: 2019-03-22
• 授与年月日（W3CDTF）: 2019-03-22
• 報告番号: 甲第3281号
• 学位: 博士（歯学）
• 博論授与番号: 甲第3281号
• 本文の言語コード: eng
• 件名標目: Carbon nanotube; Taquann methods; alveolar macrophage; fibrosis; lung
• 対象利用者: 一般
• 一般注記: BackgroundNanomaterials are widely used in various fields. Although the toxicity of carbon nanotubes (CNTs) in pulmonary tissues has been demonstrated, the toxicological effect of CNTs on the immune system in the lung remains unclear.Methods and findingIn this study, exposure to Taquann-treated multi-walled CNTs (T-CNTs) was performed using aerosols generated in an inhalation chamber. At 12 months after T-CNT exposure, alveolar inflammation with macrophage accumulation and hypertrophy of the alveolar walls were observed. In addition, fibrotic lesions were enhanced by T-CNT exposure. The macrophages in the bronchoalveolar lavage fluid of T-CNT-exposed mice were not largely shifted to any particular population, and were a mixed phenotype with M1 and M2 polarization. Moreover, the alveolar macrophages of T-CNT-exposed mice produced matrix metalloprotinase-12.ConclusionsThese results suggest that T-CNT exposure promoted chronic inflammation and fibrotic lesion formation in profibrotic macrophages for prolonged periods.
• DOI: info:doi/10.1371/journal.pone.0205702; https://doi.org/info:doi/10.1371/journal.pone.0205702
• 国立国会図書館永続的識別子: info:ndljp/pid/11300550; https://dl.ndl.go.jp/pid/11300550
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2019-07-05T01:13:02+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://repo.lib.tokushima-u.ac.jp/113371
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp