Long-term polarization of alveolar macrophages to a profibrotic phenotype after inhalation exposure to multi-wall carbon nanotubes

Persistent ID (NDL): info:ndljp/pid/11300550

Material type: 博士論文

Author: Otsuka, Kunihiroほか

Publisher: PLOS

Publication date: 2018-10-29

Material Format: Digital

Capacity, size, etc.: -

Name of awarding university/degree: 徳島大学,博士（歯学）

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Note (General)：: BackgroundNanomaterials are widely used in various fields. Although the toxicity of carbon nanotubes (CNTs) in pulmonary tissues has been demonstrated...

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Material Type: 博士論文
ISSN: 1932-6203
Title: Long-term polarization of alveolar macrophages to a profibrotic phenotype after inhalation exposure to multi-wall carbon nanotubes
Volume: 13 10
Author/Editor: Otsuka, Kunihiro
Yamada, Koichi
Taquahashi, Yuhji
Arakaki, Rieko
Ushio, Aya
Saito, Masako
Yamada, Akiko
Tsunematsu, Takaaki
Kudo, Yasusei
Kanno, Jun
Ishimaru, Naozumi
Author Heading: Otsuka, Kunihiro
Yamada, Koichi
Taquahashi, Yuhji
Arakaki, Rieko
Ushio, Aya
Saito, Masako
Yamada, Akiko
Tsunematsu, Takaaki
Kudo, Yasusei
Kanno, Jun
Ishimaru, Naozumi
Publication, Distribution, etc.: PLOS
Publication Date: 2018-10-29
Publication Date (W3CDTF): 2018-10-29
Alternative Title: 多層カーボンナノチューブの吸入曝露による線維化誘導型肺胞マクロファージへの長期変化
Effect of CNT exposure on alveolar macrophages
Periodical title: PLOS ONE
Degree grantor/type: 徳島大学
Date Granted: 2019-03-22
Date Granted (W3CDTF): 2019-03-22
Dissertation Number: 甲第3281号
Degree Type: 博士（歯学）
Conferring No. (Dissertation): 甲第3281号
Text Language Code: eng
Subject Heading: Carbon nanotube
Taquann methods
alveolar macrophage
fibrosis
lung
Target Audience: 一般
Note (General): BackgroundNanomaterials are widely used in various fields. Although the toxicity of carbon nanotubes (CNTs) in pulmonary tissues has been demonstrated, the toxicological effect of CNTs on the immune system in the lung remains unclear.Methods and findingIn this study, exposure to Taquann-treated multi-walled CNTs (T-CNTs) was performed using aerosols generated in an inhalation chamber. At 12 months after T-CNT exposure, alveolar inflammation with macrophage accumulation and hypertrophy of the alveolar walls were observed. In addition, fibrotic lesions were enhanced by T-CNT exposure. The macrophages in the bronchoalveolar lavage fluid of T-CNT-exposed mice were not largely shifted to any particular population, and were a mixed phenotype with M1 and M2 polarization. Moreover, the alveolar macrophages of T-CNT-exposed mice produced matrix metalloprotinase-12.ConclusionsThese results suggest that T-CNT exposure promoted chronic inflammation and fibrotic lesion formation in profibrotic macrophages for prolonged periods.
DOI: info:doi/10.1371/journal.pone.0205702
https://doi.org/info:doi/10.1371/journal.pone.0205702
Persistent ID (NDL): info:ndljp/pid/11300550
https://dl.ndl.go.jp/pid/11300550
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2019-07-05T01:13:02+09:00
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/113371
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
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