Lipopolysaccharide promotes early endometrial-peritoneal interactions in a mouse model of endometriosis

• 資料種別: 博士論文
• ISSN: 1349-6867
• タイトル: Lipopolysaccharide promotes early endometrial-peritoneal interactions in a mouse model of endometriosis
• 巻次・部編番号: 66 1-2
• 著者・編者: Keyama, Kaoru; Kato, Takeshi; Kadota, Yuri; Erdenebayar, Otgontsetseg; Kasai, Kana; Kawakita, Takako; Tani, Anna; Matsui, Sumika; Iwasa, Takeshi; Yoshida, Kanako; Maegawa, Masahiko; Kuwahara, Akira; Matsuzaki, Toshiya; Irahara, Minoru
• 著者標目: Keyama, Kaoru; Kato, Takeshi; Kadota, Yuri; Erdenebayar, Otgontsetseg; Kasai, Kana; Kawakita, Takako; Tani, Anna; Matsui, Sumika; Iwasa, Takeshi; Yoshida, Kanako; Maegawa, Masahiko; Kuwahara, Akira; Matsuzaki, Toshiya; Irahara, Minoru
• 出版事項: Tokushima University Faculty of Medicine
• 出版年月日等: 2019-02
• 出版年（W3CDTF）: 2019-02
• 並列タイトル等: 子宮内膜症モデルマウスにおいてLPSは腹膜子宮内膜症初期病巣形成を促進する; LPS proliferate the endometriosis
• タイトル（掲載誌）: The Journal of Medical Investigation
• 授与機関名: 徳島大学
• 授与年月日: 2018-12-27
• 授与年月日（W3CDTF）: 2018-12-27
• 報告番号: 甲第3248号
• 学位: 博士（医学）
• 博論授与番号: 甲第3248号
• 本文の言語コード: eng
• 件名標目: LPS; endometriosis; inflammation; Murine model; cytokine; mice model
• 対象利用者: 一般
• 一般注記: Purpose : The aims of this study were to clarify the effects of lipopolysaccharide (LPS) on the early development of endometriosis and on the production of cytokines and chemokines in the murine peritoneal cavity. Methods : Endometriotic lesions were induced in C57BL/6J adult female mice by intraperitoneal injection of endometrial fragments plus blood or endometrial fragments plus blood with LPS. On day 7, endometriotic lesions were assessed by gross and microscopic evaluations. Time-dependent changes in the secretion of TNF-α, IL-6, and CXCL2/MIP-2 in peritoneal lavage fluid after the intraperitoneal injection of LPS (50 µg/body) were measured by their respective enzyme-linked immunosorbent assays. Results : The areas of endometriotic lesions in the LPS group (10.8±8.6 mm2) were significantly larger than those in the control group (3.1±3.7 mm2). The levels of TNF-α and IL-6 peaked within 2 hours and the level of MIP-2 reached a maximum on day 1 after the injection of LPS. Conclusions : LPS promotes development of the early stages of murine endometriotic lesions.
• DOI: info:doi/10.2152/jmi.66.70; https://doi.org/info:doi/10.2152/jmi.66.70
• 国立国会図書館永続的識別子: info:ndljp/pid/11344402; https://dl.ndl.go.jp/pid/11344402
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2019-09-04T09:14:56+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://repo.lib.tokushima-u.ac.jp/113324
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp