Lipopolysaccharide promotes early endometrial-peritoneal interactions in a mouse model of endometriosis 1-2

• Material Type: 博士論文
• Title: Lipopolysaccharide promotes early endometrial-peritoneal interactions in a mouse model of endometriosis
• Volume: 66 1-2
• Author/Editor: Keyama, Kaoru; Kato, Takeshi; Kadota, Yuri; Erdenebayar, Otgontsetseg; Kasai, Kana; Kawakita, Takako; Tani, Anna; Matsui, Sumika; Iwasa, Takeshi; Yoshida, Kanako; Maegawa, Masahiko; Kuwahara, Akira; Matsuzaki, Toshiya; Irahara, Minoru
• Author Heading: Keyama, Kaoru; Kato, Takeshi; Kadota, Yuri; Erdenebayar, Otgontsetseg; Kasai, Kana; Kawakita, Takako; Tani, Anna; Matsui, Sumika; Iwasa, Takeshi; Yoshida, Kanako; Maegawa, Masahiko; Kuwahara, Akira; Matsuzaki, Toshiya; Irahara, Minoru
• Publication, Distribution, etc.: Tokushima University Faculty of Medicine
• Publication Date: 2019-02
• Publication Date (W3CDTF): 2019-02
• Alternative Title: 子宮内膜症モデルマウスにおいてLPSは腹膜子宮内膜症初期病巣形成を促進する; LPS proliferate the endometriosis
• Periodical title: The Journal of Medical Investigation
• Degree grantor/type: 徳島大学
• Date Granted: 2018-12-27
• Date Granted (W3CDTF): 2018-12-27
• Dissertation Number: 甲第3248号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第3248号
• Text Language Code: eng
• Subject Heading: LPS; endometriosis; inflammation; Murine model; cytokine; mice model
• Target Audience: 一般
• Note (General): Purpose : The aims of this study were to clarify the effects of lipopolysaccharide (LPS) on the early development of endometriosis and on the production of cytokines and chemokines in the murine peritoneal cavity. Methods : Endometriotic lesions were induced in C57BL/6J adult female mice by intraperitoneal injection of endometrial fragments plus blood or endometrial fragments plus blood with LPS. On day 7, endometriotic lesions were assessed by gross and microscopic evaluations. Time-dependent changes in the secretion of TNF-α, IL-6, and CXCL2/MIP-2 in peritoneal lavage fluid after the intraperitoneal injection of LPS (50 µg/body) were measured by their respective enzyme-linked immunosorbent assays. Results : The areas of endometriotic lesions in the LPS group (10.8±8.6 mm2) were significantly larger than those in the control group (3.1±3.7 mm2). The levels of TNF-α and IL-6 peaked within 2 hours and the level of MIP-2 reached a maximum on day 1 after the injection of LPS. Conclusions : LPS promotes development of the early stages of murine endometriotic lesions.
• DOI: info:doi/10.2152/jmi.66.70; https://doi.org/info:doi/10.2152/jmi.66.70
• Persistent ID (NDL): info:ndljp/pid/11344402; https://dl.ndl.go.jp/pid/11344402
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2019-09-04T09:14:56+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/113324
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp