A microgravity environment improves structural resolution and endows cues for specific inhibition of mitogen-activated protein kinase kinase 7

• 資料種別: 記事
• タイトル: A microgravity environment improves structural resolution and endows cues for specific inhibition of mitogen-activated protein kinase kinase 7
• 著者・編者: Takayoshi Kinoshita; Takuma Hashimoto; Yuka Murakawa
• 出版事項: 日本 : 日本マイクログラビティ応用学会
• 出版年月日等: 2019-01-31
• 出版年（W3CDTF）: 2019-01-31
• タイトル（掲載誌）: International journal of microgravity science and application : IJMSA
• 巻号年月日等（掲載誌）: 36(1)
• 掲載巻: 36(1)
• ISSN（掲載誌）: 2188-9783
• ISSN-L（掲載誌）: 0915-3616
• 本文の言語コード: eng
• DOI: 10.15011//jasma.36.360102; https://doi.org/10.15011//jasma.36.360102
• 国立国会図書館永続的識別子: info:ndljp/pid/11374503; https://dl.ndl.go.jp/pid/11374503
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > 電子書籍・電子雑誌 > 学術機関 > 学協会; https://dl.ndl.go.jp/collections/B00043
• 収集根拠: オンライン資料収集制度
• 受理日（W3CDTF）: 2019-10-16T20:43:03+09:00
• 保存日（W3CDTF）: 2019-02-22
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: https://www.jasma.info/journal/archives/report/a-microgravity-environment-improves-structural-resolution-and-endows-cues-for-specific-inhibition-of-mitogen-activated-protein-kinase-kinase-7
• 掲載誌（国立国会図書館永続的識別子）: info:ndljp/pid/11374499; https://dl.ndl.go.jp/pid/11374499
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

• 要約等: Mitogen-activated protein kinase kinase 7 (MAP2K7) regulates stress and inflammatory responses, and is an attractive drug discovery target for serious diseases such as arthritis and cardiac hypertrophy. A microgravity environment improved the crystal quality of MAP2K7 and improved the structural resolution to 1.3 Å. High resolution analysis structurally clarified the two regions, which were undefined in the previous low-resolution analysis and conferred structural insights for producing MAP2K7-specific inhibitors. The hinge region alternatively configures the canonical and atypical conformations. The latter could allow binding MAP2K7 inhibitors with a novel scaffold. The C-terminal region works as a negative regulator with intermolecular association, which implies the ability to produce highly selective MAP2K7 inhibitors.
• DOI: 10.15011//jasma.36.360102
• オンライン閲覧公開範囲: インターネット公開
• 連携機関・データベース: 科学技術振興機構 : J-STAGE; http://www.jstage.jst.go.jp

• 要約等: Mitogen-activated protein kinase kinase 7 (MAP2K7) regulates stress and inflammatory responses, and is an attractive drug discovery target for serious diseases such as arthritis and cardiac hypertrophy. A microgravity environment improved the crystal quality of MAP2K7 and improved the structural resolution to 1.3 Å. High resolution analysis structurally clarified the two regions, which were undefined in the previous low-resolution analysis and conferred structural insights for producing MAP2K7-specific inhibitors. The hinge region alternatively configures the canonical and atypical conformations. The latter could allow binding MAP2K7 inhibitors with a novel scaffold. The C-terminal region works as a negative regulator with intermolecular association, which implies the ability to produce highly selective MAP2K7 inhibitors.
• DOI: 10.15011//jasma.36.360102; https://doi.org/10.15011//jasma.36.360102
• 関連情報（URI）: http://id.ndl.go.jp/digimeta/11374503; https://dl.ndl.go.jp/pid/11374503
• 連携機関・データベース: 国立情報学研究所 : CiNii Research; https://cir.nii.ac.jp/
• 提供元機関・データベース: Japan Link Center; https://japanlinkcenter.org/top; 雑誌記事索引データベース; https://ndlsearch.ndl.go.jp; CiNii Articles
• 書誌ID（NDLBibID）: 11374503; http://id.ndl.go.jp/bib/11374503
• NII論文ID: 130007769925