A microgravity environment improves structural resolution and endows cues for specific inhibition of mitogen-activated protein kinase kinase 7
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DOI[10.15011//jasma.36.360102]to the data of the same series
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- Material Type
- 記事
- Author/Editor
- Takayoshi KinoshitaTakuma HashimotoYuka Murakawa
- Publication, Distribution, etc.
- Publication Date
- 2019-01-31
- Publication Date (W3CDTF)
- 2019-01-31
- Periodical title
- International journal of microgravity science and application : IJMSA
- No. or year of volume/issue
- 36(1)
- Volume
- 36(1)
- ISSN (Periodical Title)
- 2188-9783
- ISSN-L (Periodical Title)
- 0915-3616
- Text Language Code
- eng
- DOI
- 10.15011//jasma.36.360102
- Persistent ID (NDL)
- info:ndljp/pid/11374503
- Collection
- Collection (Materials For Handicapped People:1)
- Collection (particular)
- 国立国会図書館デジタルコレクション > 電子書籍・電子雑誌 > 学術機関 > 学協会
- Acquisition Basis
- オンライン資料収集制度
- Date Accepted (W3CDTF)
- 2019-10-16T20:43:03+09:00
- Date Captured (W3CDTF)
- 2019-02-22
- Format (IMT)
- application/pdf
- Access Restrictions
- 国立国会図書館内限定公開
- Service for the Digitized Contents Transmission Service
- 図書館・個人送信対象外
- Availability of remote photoduplication service
- 可
- Periodical Title (URI)
- Periodical Title (Persistent ID (NDL))
- info:ndljp/pid/11374499
- Data Provider (Database)
- 国立国会図書館 : 国立国会図書館デジタルコレクション
- Summary, etc.
- Mitogen-activated protein kinase kinase 7 (MAP2K7) regulates stress and inflammatory responses, and is an attractive drug discovery target for serious diseases such as arthritis and cardiac hypertrophy. A microgravity environment improved the crystal quality of MAP2K7 and improved the structural resolution to 1.3 Å. High resolution analysis structurally clarified the two regions, which were undefined in the previous low-resolution analysis and conferred structural insights for producing MAP2K7-specific inhibitors. The hinge region alternatively configures the canonical and atypical conformations. The latter could allow binding MAP2K7 inhibitors with a novel scaffold. The C-terminal region works as a negative regulator with intermolecular association, which implies the ability to produce highly selective MAP2K7 inhibitors.
- DOI
- 10.15011//jasma.36.360102
- Access Restrictions
- インターネット公開
- Data Provider (Database)
- 科学技術振興機構 : J-STAGE
- Summary, etc.
- Mitogen-activated protein kinase kinase 7 (MAP2K7) regulates stress and inflammatory responses, and is an attractive drug discovery target for serious diseases such as arthritis and cardiac hypertrophy. A microgravity environment improved the crystal quality of MAP2K7 and improved the structural resolution to 1.3 Å. High resolution analysis structurally clarified the two regions, which were undefined in the previous low-resolution analysis and conferred structural insights for producing MAP2K7-specific inhibitors. The hinge region alternatively configures the canonical and atypical conformations. The latter could allow binding MAP2K7 inhibitors with a novel scaffold. The C-terminal region works as a negative regulator with intermolecular association, which implies the ability to produce highly selective MAP2K7 inhibitors.
- DOI
- 10.15011//jasma.36.360102
- Related Material (URI)
- Data Provider (Database)
- 国立情報学研究所 : CiNii Research
- Original Data Provider (Database)
- Japan Link Center雑誌記事索引データベースCiNii Articles
- Bibliographic ID (NDL)
- 11374503
- NAID
- 130007769925