Distinct spatial localization of three types of phosphatidyl choline in rat buccal mucosa identified by matrix-assisted laser desorption/ionization imaging mass spectrometry 1

• 資料種別: 博士論文
• ISSN: 2432-7441
• タイトル: Distinct spatial localization of three types of phosphatidyl choline in rat buccal mucosa identified by matrix-assisted laser desorption/ionization imaging mass spectrometry
• 巻次・部編番号: 1 1
• 著者・編者: 宮城, 摩里子
• 著者標目: 宮城, 摩里子
• 出版年月日等: 2017-06
• 出版年（W3CDTF）: 2017-06
• 並列タイトル等: マトリックス支援レーザー脱離イオン化質量分析イメージングにより明らかになったラット頬粘膜における3種類のリン脂質の異なる分布
• タイトル（掲載誌）: Medical Mass Spectrometry
• 授与機関名: 浜松医科大学
• 授与年月日: 2019-03-13
• 授与年月日（W3CDTF）: 2019-03-13
• 報告番号: 甲第805号
• 学位: 博士（医学）
• 博論授与番号: 甲第805号
• 本文の言語コード: eng
• 件名標目: imaging mass spectrometry; buccal mucosa; phosphatidylcholine; mass microscopy; matrix assisted laser desorption/ionization
• 対象利用者: 一般
• 一般注記: doctoral; 医学系研究科; The buccal mucosa is an inner lining exposed to frequent friction caused by teeth occlusion and therefore, a vulnerable site to lesions such as stomatitis, leukoplakia, lichen planus and cancer. Although it is considered an important tissue in the field of oral surgery, not enough information regarding the buccal mucosa is available. In this study, we characterized the buccal mucosa in the oral cavity using imaging mass spectrometry (IMS). Tissues such as epithelium, lamina propria and muscle were identified in rat buccal mucosa by HE staining. Moreover, IMS data of high-intensity ions were classified into 4 groups according to their distribution. In a previous IMS analysis of mouse tongue tissue, we detected linoleic acid-containing phosphatidyl choline (PC)(diacyl 16:0/18:2), oleic acid-containing PC(diacyl 16:0/18:1) and DHA-containing PC(diacyl 16:0/22:6) as major PCs. In the present work, we analyzed buccal mucosa tissue with emphasis on the aforementioned PC by IMS and showed that the investigated PCs existed in the layers of epithelium, lamina propria, and muscle at different ratios. This is the first study to analyze by IMS the buccal mucosa. The results presented here are likely to provide the perspective on understanding oral environments and to develop treatments for oral disorders.
• DOI: info:doi/10.24508/mms.2017.06.002; https://doi.org/info:doi/10.24508/mms.2017.06.002
• 国立国会図書館永続的識別子: info:ndljp/pid/11429077; https://dl.ndl.go.jp/pid/11429077
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2020-01-15T13:48:52+09:00
• 作成日（W3CDTF）: 2019-12-05
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://hdl.handle.net/10271/00003669; https://hama-med.repo.nii.ac.jp/records/3532
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

目次

2023-12-09 再収集