Distinct spatial localization of three types of phosphatidyl choline in rat buccal mucosa identified by matrix-assisted laser desorption/ionization imaging mass spectrometry

• Material Type: 博士論文
• ISSN: 2432-7441
• Title: Distinct spatial localization of three types of phosphatidyl choline in rat buccal mucosa identified by matrix-assisted laser desorption/ionization imaging mass spectrometry
• Volume: 1 1
• Author/Editor: 宮城, 摩里子
• Author Heading: 宮城, 摩里子
• Publication, Distribution, etc.: 日本医用マススペクトル学会
• Publication Date: 2017-06
• Publication Date (W3CDTF): 2017-06
• Alternative Title: マトリックス支援レーザー脱離イオン化質量分析イメージングにより明らかになったラット頬粘膜における3種類のリン脂質の異なる分布
• Periodical title: Medical Mass Spectrometry
• Degree grantor/type: 浜松医科大学
• Date Granted: 2019-03-13
• Date Granted (W3CDTF): 2019-03-13
• Dissertation Number: 甲第805号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第805号
• Text Language Code: eng
• Subject Heading: imaging mass spectrometry; buccal mucosa; phosphatidylcholine; mass microscopy; matrix assisted laser desorption/ionization
• Target Audience: 一般
• Note (General): doctoral; 医学系研究科; The buccal mucosa is an inner lining exposed to frequent friction caused by teeth occlusion and therefore, a vulnerable site to lesions such as stomatitis, leukoplakia, lichen planus and cancer. Although it is considered an important tissue in the field of oral surgery, not enough information regarding the buccal mucosa is available. In this study, we characterized the buccal mucosa in the oral cavity using imaging mass spectrometry (IMS). Tissues such as epithelium, lamina propria and muscle were identified in rat buccal mucosa by HE staining. Moreover, IMS data of high-intensity ions were classified into 4 groups according to their distribution. In a previous IMS analysis of mouse tongue tissue, we detected linoleic acid-containing phosphatidyl choline (PC)(diacyl 16:0/18:2), oleic acid-containing PC(diacyl 16:0/18:1) and DHA-containing PC(diacyl 16:0/22:6) as major PCs. In the present work, we analyzed buccal mucosa tissue with emphasis on the aforementioned PC by IMS and showed that the investigated PCs existed in the layers of epithelium, lamina propria, and muscle at different ratios. This is the first study to analyze by IMS the buccal mucosa. The results presented here are likely to provide the perspective on understanding oral environments and to develop treatments for oral disorders.
• DOI: info:doi/10.24508/mms.2017.06.002; https://doi.org/info:doi/10.24508/mms.2017.06.002
• Persistent ID (NDL): info:ndljp/pid/11429077; https://dl.ndl.go.jp/pid/11429077
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2020-01-15T13:48:52+09:00
• Date Created (W3CDTF): 2019-12-05
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10271/00003669; https://hama-med.repo.nii.ac.jp/records/3532
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2023-12-09 再収集