並列タイトル等Dynamics of Soluble Thrombomodulin and Circulating miRNAs in Patlents with Atrial Fibrillation Undergoing Radiofrequency Catheter Ablation
タイトル（掲載誌）Clinical and Applied Thrombosis/Hemostasis
学位博士(医学)
Doctor of Philosophy in Medical Science
一般注記博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨
Atrial fibrillation (AF) is the most common cardiac arrhythmia in the world and has a high risk of thromboembolism. The most effective approach, catheter ablation, requires evaluation by electrocardiography. The aim of our study was to investigate novel clinical markers that predict restoration of sinus rhythm (SR) after catheter ablation. Seventy-eight consecutive patients with AF underwent catheter ablation and were separated into 2 groups: restored SR and recurrent AF. The levels of 4 blood proteins (serum or plasma) and 3 mature microRNAs (miRNAs) and their primary miRNAs (pri-miRNAs) in serum were measured before and after ablation, and the associations between each parameter were analyzed statistically. Soluble thrombomodulin (s-TM) and plasminogen activator inhibitor-1 (PAI-1) levels increased above baseline after ablation in both the restored SR (s-TM 11.55 [2.92] vs 13.75 [3.38], P < .001; PAI-1 25.74 [15.25] vs 37.79 [19.56], P < .001) and recurrent AF (s-TM 10.28 [2.78] vs 11.67 [3.37], P < .001; PAI-1 26.16 [15.70] vs 40.74 [22.55], P < .001) groups. Levels of C-reactive protein and asymmetric dimethylarginine were not significantly changed. Pri-miR-126 levels significantly decreased after ablation in the recurrent AF group, but the other miRNAs and pri-miRNAs did not. The measurement of s-TM and pri-miR-126 in blood was a useful tool to reflect the condition of AF patients with catheter ablation.Namino F. Yamakuchi M. Iriki Y. Okui H. Ichiki H. Maenosono R. Oketani N. Masamoto I. Miyata M. Horiuchi M. Hashiguchi T. Ohishi M. Maruyama I.Dynamics of Soluble Thrombomodulin and Circulating miRNAs in Patlents with Atrial Fibrillation Undergoing Radiofrequency Catheter AblationClinical and Applied Thrombosis/Hemostasis Volume 25: 1-11https://doi.org/10.1177/1076029619851570
DOIinfo:doi/10.1177/1076029619851570
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