高周波カテーテルアブレーション治療を施行した心房細動患者における可溶性トロンポモジュリンと循環miRNAの動態

• Material Type: 博士論文
• Title: 高周波カテーテルアブレーション治療を施行した心房細動患者における可溶性トロンポモジュリンと循環miRNAの動態
• Volume: 25
• Author/Editor: 波野, 史典
• Author Heading: 波野, 史典
• Publication, Distribution, etc.: SAGE
• Publication Date: 2019; 25
• Publication Date (W3CDTF): 2019
• Alternative Title: Dynamics of Soluble Thrombomodulin and Circulating miRNAs in Patlents with Atrial Fibrillation Undergoing Radiofrequency Catheter Ablation
• Periodical title: Clinical and Applied Thrombosis/Hemostasis
• Degree grantor/type: 鹿児島大学
• Date Granted: 2019-11-20
• Date Granted (W3CDTF): 2019-11-20
• Dissertation Number: 甲総研第525号
• Degree Type: 博士(医学); Doctor of Philosophy in Medical Science
• Conferring No. (Dissertation): 甲総研第525号
• Text Language Code: eng
• Subject Heading: atrial fibrillation; catheter ablation; soluble thrombomodulin; plasminogen activator inhibitor-1; miRNA; primary miRNA
• NDC: 490
• Target Audience: 一般
• Note (General): 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨; Atrial fibrillation (AF) is the most common cardiac arrhythmia in the world and has a high risk of thromboembolism. The most effective approach, catheter ablation, requires evaluation by electrocardiography. The aim of our study was to investigate novel clinical markers that predict restoration of sinus rhythm (SR) after catheter ablation. Seventy-eight consecutive patients with AF underwent catheter ablation and were separated into 2 groups: restored SR and recurrent AF. The levels of 4 blood proteins (serum or plasma) and 3 mature microRNAs (miRNAs) and their primary miRNAs (pri-miRNAs) in serum were measured before and after ablation, and the associations between each parameter were analyzed statistically. Soluble thrombomodulin (s-TM) and plasminogen activator inhibitor-1 (PAI-1) levels increased above baseline after ablation in both the restored SR (s-TM 11.55 [2.92] vs 13.75 [3.38], P < .001; PAI-1 25.74 [15.25] vs 37.79 [19.56], P < .001) and recurrent AF (s-TM 10.28 [2.78] vs 11.67 [3.37], P < .001; PAI-1 26.16 [15.70] vs 40.74 [22.55], P < .001) groups. Levels of C-reactive protein and asymmetric dimethylarginine were not significantly changed. Pri-miR-126 levels significantly decreased after ablation in the recurrent AF group, but the other miRNAs and pri-miRNAs did not. The measurement of s-TM and pri-miR-126 in blood was a useful tool to reflect the condition of AF patients with catheter ablation.Namino F. Yamakuchi M. Iriki Y. Okui H. Ichiki H. Maenosono R. Oketani N. Masamoto I. Miyata M. Horiuchi M. Hashiguchi T. Ohishi M. Maruyama I.Dynamics of Soluble Thrombomodulin and Circulating miRNAs in Patlents with Atrial Fibrillation Undergoing Radiofrequency Catheter AblationClinical and Applied Thrombosis/Hemostasis Volume 25: 1-11https://doi.org/10.1177/1076029619851570
• DOI: info:doi/10.1177/1076029619851570; https://doi.org/info:doi/10.1177/1076029619851570
• Persistent ID (NDL): info:ndljp/pid/11449971; https://dl.ndl.go.jp/pid/11449971
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2020-02-10T02:20:18+09:00
• Date Created (W3CDTF): 2019-11-26
• Format (IMT): PDF; application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10232/00030841
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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