並列タイトル等大腸カプセル内視鏡を用いた粘膜治癒評価は臨床的寛解期潰瘍性大腸炎患者の再燃を予測する
タイトル（掲載誌）World journal of clinical cases
一般注記doctoral
医学系研究科
AIMTo examine whether second generation of colon capsule endoscopy (CCE-2) is acceptable for assessing the severity of mucosal inflammation and evaluating mucosal healing using CCE-2 is able to predict outcome in ulcerative colitis (UC) patients, especially in clinical remission.METHODSA total of 30 consecutive UC patients in clinical remission were enrolled to undergo CCE-2. Clinical remission was defined as clinical activity index (CAI) ?4 according to Rachmilewitz index. The rate of total colon observation and colon cleansing level were evaluated. Severity of mucosal inflammation in UC was assessed according to the Mayo endoscopic subscore (MES) and Ulcerative Colitis Endoscopic Index of Severity (UCEIS). Relapse-free survival was assessed. Acceptability of CCE-2 was assessed using a questionnaire survey.RESULTSThe rate of total colon observation within its battery life was 93.3%. The proportion of “excellent” plus “good” cleansing level was 73.3%. The rate of mucosal healing (MES 0,1) assessed by CCE-2 was 77.0%. The relapse-free survival rate was significantly higher in MES 0,1 than in MES 2,3 (P=0.0435), and in UCEIS 0-3 than in UCEIS 4-8 (P=0.0211), whereas there was no significant difference between CAI 0 and CAI 1-4 groups. A questionnaire survey revealed an overall acceptability of CCE.CONCLUSIONCCE-2 is acceptable for assessing the severity of mucosal inflammation in UC patients, especially in clinical remission. Evaluating mucosal healing using CCE-2 was able to predict outcome.
DOIinfo:doi/10.12998/wjcc.v6.i15.952
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