Evaluating mucosal healing using colon capsule endoscopy predicts outcome in patients with ulcerative colitis in clinical remission

• Material Type: 博士論文
• ISSN: 2307-8960
• Title: Evaluating mucosal healing using colon capsule endoscopy predicts outcome in patients with ulcerative colitis in clinical remission
• Volume: 6 15
• Author/Editor: 高野, 亮佑
• Author Heading: 高野, 亮佑
• Publication, Distribution, etc.: Baishideng Publishing Group
• Publication Date: 2018-12-06
• Publication Date (W3CDTF): 2018-12-06
• Alternative Title: 大腸カプセル内視鏡を用いた粘膜治癒評価は臨床的寛解期潰瘍性大腸炎患者の再燃を予測する
• Periodical title: World journal of clinical cases
• Degree grantor/type: 浜松医科大学
• Date Granted: 2019-12-13
• Date Granted (W3CDTF): 2019-12-13
• Dissertation Number: 甲第820号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第820号
• Text Language Code: eng
• Subject Heading: Colon capsule endoscopy; Ulcerative colitis; Mucosal healing; Mayo endoscopic subscore; Ulcerative Colitis Endoscopic Index of Severity
• Target Audience: 一般
• Note (General): doctoral; 医学系研究科; AIMTo examine whether second generation of colon capsule endoscopy (CCE-2) is acceptable for assessing the severity of mucosal inflammation and evaluating mucosal healing using CCE-2 is able to predict outcome in ulcerative colitis (UC) patients, especially in clinical remission.METHODSA total of 30 consecutive UC patients in clinical remission were enrolled to undergo CCE-2. Clinical remission was defined as clinical activity index (CAI) ?4 according to Rachmilewitz index. The rate of total colon observation and colon cleansing level were evaluated. Severity of mucosal inflammation in UC was assessed according to the Mayo endoscopic subscore (MES) and Ulcerative Colitis Endoscopic Index of Severity (UCEIS). Relapse-free survival was assessed. Acceptability of CCE-2 was assessed using a questionnaire survey.RESULTSThe rate of total colon observation within its battery life was 93.3%. The proportion of “excellent” plus “good” cleansing level was 73.3%. The rate of mucosal healing (MES 0,1) assessed by CCE-2 was 77.0%. The relapse-free survival rate was significantly higher in MES 0,1 than in MES 2,3 (P=0.0435), and in UCEIS 0-3 than in UCEIS 4-8 (P=0.0211), whereas there was no significant difference between CAI 0 and CAI 1-4 groups. A questionnaire survey revealed an overall acceptability of CCE.CONCLUSIONCCE-2 is acceptable for assessing the severity of mucosal inflammation in UC patients, especially in clinical remission. Evaluating mucosal healing using CCE-2 was able to predict outcome.
• DOI: info:doi/10.12998/wjcc.v6.i15.952; https://doi.org/info:doi/10.12998/wjcc.v6.i15.952
• Persistent ID (NDL): info:ndljp/pid/11498571; https://dl.ndl.go.jp/pid/11498571
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2020-06-07T00:39:19+09:00
• Date Created (W3CDTF): 2020-04-28
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10271/00003717; https://hama-med.repo.nii.ac.jp/records/3584
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

Table of Contents

2023-12-08 再収集