Insight into innate immune response in “Yusho”: The impact of natural killer cell and regulatory T cell on inflammatory prone diathesis of Yusho patients

• 資料種別: 博士論文
• ISSN: 0013-9351
• タイトル: Insight into innate immune response in “Yusho”: The impact of natural killer cell and regulatory T cell on inflammatory prone diathesis of Yusho patients
• 巻次・部編番号: 185
• 著者・編者: 神尾, 芳幸
• 著者標目: 神尾, 芳幸
• 出版事項: Elsevier Inc.
• 出版年月日等: 2020-06-03
• 出版年（W3CDTF）: 2020-06-03
• 並列タイトル等: “油症”における免疫応答の考察：油症患者の炎症を生じやすい素因におけるNK細胞とTreg細胞の役割
• タイトル（掲載誌）: Environmental Research
• 授与機関名: Nagasaki University (長崎大学)
• 授与年月日: 2020-06-03
• 授与年月日（W3CDTF）: 2020-06-03
• 報告番号: 甲医歯薬第1254号
• 学位: 博士(医学)
• 博論授与番号: 甲医歯薬第1254号
• 本文の言語コード: eng
• 件名標目: Dioxins; Yusho; Natural killer cells; Suppuration; Innate immunity; Cytokines
• 対象利用者: 一般
• 一般注記: Background: In 1968 in western Japan, polychlorinated biphenyl-contaminated “Kanemi rice oil” was used in cooking, causing food poisoning in many people. More than 50 years have passed since the Yusho incident, and although inflammatory disorders such as suppuration have been observed in Yusho patients, the etiology of this inflammation susceptibility remains obscure. Objectives: To investigate the mechanisms of susceptibility to inflammation in Yusho patients, peripheral immune cell fractions and concentrations of inflammatory cytokines were evaluated in blood samples collected from both Yusho patients and age-matched healthy subjects undergoing medical examination in Nagasaki. Methods: To exclude diagnostic uncertainty, serum levels of polychlorinated biphenyl (PCB), polychlorinated quarterphenyl (PCQ), and polychlorinated dibenzofuran (PCDF) were measured. Immune cell (e.g. natural killer and regulatory T cell) populations were analyzed by flow cytometry. Serum cytokines involved in immune cell activation were measured by ELISA. Results: The relative proportion of natural killer cells was higher in Yusho patients than in healthy subjects, while the proportion of regulatory T cells did not differ between groups. Serum concentrations of IL-36 and IFN-γ were significantly lower in Yusho patients than in healthy subjects. Conversely, serum cytotoxic T lymphocyte-associated antigen-4 (CTLA-4), which is a cytokine related to activated NK cells, was higher in Yusho patients than in healthy subjects and was positively correlated with PCDF blood levels. Conclusion: Increased numbers of NK cells in Yusho patients suggests that the innate immune response has been activated in Yusho patients. The seemingly paradoxical results for CTLA-4 and IFN-γ may reflect counterbalancing mechanisms preventing excessive NK cell activation. This dysregulation of innate immunity might contribute to the inflammation observed in Yusho patients.; 長崎大学学位論文 学位記番号:博(医歯薬)甲第1254号 学位授与年月日:令和2年6月3日; Author: Yoshiyuki Kamio, Yumi Gunge, Yuta Koike, Yutaka Kuwatsuka, Kazuto Tsuruta, Katsunori Yanagihara, Masutaka Furue, Hiroyuki Murota; Citation: Environmental Research, 185, art.no.109415; 2020; identifier:Nagasaki University (長崎大学), 博士(医学) (2020-06-03); http://hdl.handle.net/10069/40081
• DOI: info:doi/10.1016/j.envres.2020.109415; https://doi.org/info:doi/10.1016/j.envres.2020.109415
• 国立国会図書館永続的識別子: info:ndljp/pid/11512062; https://dl.ndl.go.jp/pid/11512062
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2020-07-06T20:31:19+09:00
• 作成日（W3CDTF）: 2020-12-18
• 記録形式（IMT）: PDF
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 関連情報（URI）: http://hdl.handle.net/10069/40081
• 掲載誌（URI）: http://hdl.handle.net/10069/40034
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

目次

2021-03-07 再収集