The effects of pure potassium channel blocker nifekalant and sodium channel blocker mexiletine on malignant ventricular tachyarrhythmias

• 資料種別: 博士論文
• タイトル: The effects of pure potassium channel blocker nifekalant and sodium channel blocker mexiletine on malignant ventricular tachyarrhythmias
• 著者・編者: Otuki, Sou
• 出版年月日等: 2019-09-20
• 出版年（W3CDTF）: 2019-09-20
• 並列タイトル等: 難治性心室性不整脈に対するニフェカラント(Kチャネル遮断薬)・メキシレチン(Naチャネル遮断薬)の効果
• 授与機関名: 新潟大学
• 授与年月日: 2019-09-20
• 授与年月日（W3CDTF）: 2019-09-20
• 報告番号: 甲第4628号
• 学位: 博士(医学)
• 博論授与番号: 甲第4628号
• 本文の言語コード: eng
• 件名標目: Arrhythmias; Drugs; Sudden death; Electrical storm; Heart diseases
• 一般注記: Background: Patients with repetitive ventricular tachyarrhythmias - so-called electrical storm - frequently require antiarrhythmic drugs. Amiodarone is widely used for the treatment of electrical storm but is ineffective in some patients. Therefore, we investigated the efficacy of stepwise administration of nifekalant, a pure potassium channel blocker, and mexiletine for electrical storm. Methods: This study included 44 patients with repetitive ventricular tachyarrhythmias who received stepwise therapy with nifekalant and mexiletine for electrical storm. Nifekalant was initially administered, and mexiletine was subsequently added if nifekalant failed to control ventricular tachyarrhythmias. Results: Nifekalant completely suppressed recurrences of ventricular arrhythmias in 28 patients (64%), including 6 patients in whom oral amiodarone failed to control arrhythmias. In 9 of 16 patients in whom nifekalant was partially effective but failed to suppress ventricular arrhythmias, mexiletine was added. The addition of mexiletine prevented recurrences of ventricular tachyarrhythmias in 5 of these 9 patients (56%). There was no death associated with electrical storm. In total, the stepwise treatment with nifekalant and mexiletine was effective in preventing ventricular tachyarrhythmias in 33 of 44 patients (75%). There was no difference in cycle length of the ventricular tachycardia, QRS interval, QT interval, or left ventricular ejection fraction between patients who responded to antiarrhythmic drugs and those who did not. During follow-up, 8 patients had repetitive ventricular tachyarrhythmia recurrences, and the stepwise treatment was effective in 6 of these 8 patients (75%). Conclusions: The stepwise treatment with nifekalant and mexiletine was highly effective in the suppression of electrical storm.; Journal of Electrocardiology. 2017, 50(3), 277-281.; 新大院博(医)甲第888号; 元資料の権利情報 : 【○!C】 2016 Published by Elsevier Inc.
• DOI: info:doi/10.1016/j.jelectrocard.2016.09.005; https://doi.org/info:doi/10.1016/j.jelectrocard.2016.09.005
• 国立国会図書館永続的識別子: info:ndljp/pid/11526122; https://dl.ndl.go.jp/pid/11526122
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2020-08-11T22:41:34+09:00
• 作成日（W3CDTF）: 2020-07-08
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://hdl.handle.net/10191/00051709
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp