The effects of pure potassium channel blocker nifekalant and sodium channel blocker mexiletine on malignant ventricular tachyarrhythmias

• Material Type: 博士論文
• Title: The effects of pure potassium channel blocker nifekalant and sodium channel blocker mexiletine on malignant ventricular tachyarrhythmias
• Author/Editor: Otuki, Sou
• Publication Date: 2019-09-20
• Publication Date (W3CDTF): 2019-09-20
• Alternative Title: 難治性心室性不整脈に対するニフェカラント(Kチャネル遮断薬)・メキシレチン(Naチャネル遮断薬)の効果
• Degree grantor/type: 新潟大学
• Date Granted: 2019-09-20
• Date Granted (W3CDTF): 2019-09-20
• Dissertation Number: 甲第4628号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲第4628号
• Text Language Code: eng
• Subject Heading: Arrhythmias; Drugs; Sudden death; Electrical storm; Heart diseases
• Note (General): Background: Patients with repetitive ventricular tachyarrhythmias - so-called electrical storm - frequently require antiarrhythmic drugs. Amiodarone is widely used for the treatment of electrical storm but is ineffective in some patients. Therefore, we investigated the efficacy of stepwise administration of nifekalant, a pure potassium channel blocker, and mexiletine for electrical storm. Methods: This study included 44 patients with repetitive ventricular tachyarrhythmias who received stepwise therapy with nifekalant and mexiletine for electrical storm. Nifekalant was initially administered, and mexiletine was subsequently added if nifekalant failed to control ventricular tachyarrhythmias. Results: Nifekalant completely suppressed recurrences of ventricular arrhythmias in 28 patients (64%), including 6 patients in whom oral amiodarone failed to control arrhythmias. In 9 of 16 patients in whom nifekalant was partially effective but failed to suppress ventricular arrhythmias, mexiletine was added. The addition of mexiletine prevented recurrences of ventricular tachyarrhythmias in 5 of these 9 patients (56%). There was no death associated with electrical storm. In total, the stepwise treatment with nifekalant and mexiletine was effective in preventing ventricular tachyarrhythmias in 33 of 44 patients (75%). There was no difference in cycle length of the ventricular tachycardia, QRS interval, QT interval, or left ventricular ejection fraction between patients who responded to antiarrhythmic drugs and those who did not. During follow-up, 8 patients had repetitive ventricular tachyarrhythmia recurrences, and the stepwise treatment was effective in 6 of these 8 patients (75%). Conclusions: The stepwise treatment with nifekalant and mexiletine was highly effective in the suppression of electrical storm.; Journal of Electrocardiology. 2017, 50(3), 277-281.; 新大院博(医)甲第888号; 元資料の権利情報 : 【○!C】 2016 Published by Elsevier Inc.
• DOI: info:doi/10.1016/j.jelectrocard.2016.09.005; https://doi.org/info:doi/10.1016/j.jelectrocard.2016.09.005
• Persistent ID (NDL): info:ndljp/pid/11526122; https://dl.ndl.go.jp/pid/11526122
• Collection: 障害者向け資料
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• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2020-08-11T22:41:34+09:00
• Date Created (W3CDTF): 2020-07-08
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
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• Periodical Title (URI): http://hdl.handle.net/10191/00051709
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp