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Background and Aims: The present study aimed to assess the significance and degree of correlation between intake of fish oil, magnesium (Mg), and zinc (Zn) and metabolic parameters.Methods: Correlation coefficients among nutrient intake and physical and laboratory parameters were determined using Spearman’s rho (ρ) test or a multiple regression model among Japanese individuals (male:female, 37:66; median age, 55 years) who completed a semi- quantitative food questionnaire and underwent diabetes tests. Individuals with diabetes were excluded. Results: Spearman’s test revealed several weak but significant correlations between intake of fish oil including ω-3 polyunsaturated fatty acids (PUFA) and various metabolic parameters. The test showed that Zn intake in women significantly correlated with reduced systolic blood pressure (SBP), alanine aminotransferase (ALT), γ-glutamyl transpeptidase (γ-GTP), and homeostasis model assessment-insulin resistance (HOMA-R). Multivariate analysis revealed that intake of fish oil, eicosapentaenoic acid (EPA), and Zn was significantly associated with increased serum levels of high-density lipoprotein cholesterol (HDL-C) (fish oil vs. HDL-C, p/95%CI =0.0438/0.0055 to 0.3724; EPA vs. HDL-C, 0.0439/0.0053 to 0.3724; Zn vs. HDL-C, 0.0041/0.0890 to 0.4609). Multivariate analysis revealed that ω-3 PUFA was associated with decreased serum ALT levels (0.0240/-5.000 to -0.0367) and that Zn correlated with SBP (0.0239/-0.5149 to -0.0377) in women.Conclusion: Intake of fish oil, Mg, and Zn was associated with some metabolic parameters. Abundant intake of fish oil including ω-3 PUFA and Zn can exert anti-arteriosclerotic effects through increasing serum levels of HDL-C. Omega-3 PUFA can reduce liver inflammation and Zn reduced systolic blood pressure in women.
本文 / 三重大学大学院医学系研究科 生命医科学専攻 病態制御医学講座 消化器内科学分野
28p
DOIinfo:doi/10.1016/j.nut.2015.02.019
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