並列タイトル等情動ストレスは大縫線核(NRM)での咬筋侵害応答を増大させる
一般注記Psychophysical stress could increase nociception in the orofacial region including the masseter muscle, and neural changes in the brain contribute to increases in masseter muscle nociception under psychophysical stress conditions. The nucleus raphe magnus (NRM) located in the brain stem serves crucial roles to regulate nociception as descending pain controls. However, it remains unclear if neural activities in the NRM could be affected under psychophysical stress conditions. This study conducted experiments to assess (1) whether neural activity, indicated by Fos expression in the NRM evoked by masseter muscle injury, is modulated by the repeated forced swim stress (FST); (2) whether the selective serotonin reuptake inhibitor, fluoxetine, administered daily after FST could affect the number of Fos-positive neurons in the NRM. Results revealed that repeated forced swim stress significantly increased the number of Fos-positive neurons in the NRM evoked by masseter muscle injury. Fluoxetine inhibited increases in the number of Fos-positive neurons in the NRM in FST, but not in sham rats. These findings indicated that FST could increase in nociceptive neural activities in the NRM evoked by masseter muscle injury, which could be due to changes in serotonergic mechanisms at least, in part.
Journal of Oral Science. 2020, 62(2), 231-235.
新大院博(歯)甲第448号
開始ページ : 1
終了ページ : 15
DOIinfo:doi/10.2334/josnusd.19-0320
コレクション(個別)国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
受理日(W3CDTF)2020-09-07T06:04:08+09:00
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