Modulatory effects of repeated psychophysical stress on masseter muscle nociception in the nucleus raphe magnus of rats

Persistent ID (NDL): info:ndljp/pid/11538577

Material type: 博士論文

Author: Shimizu, Shiho

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Publication date: 2020-03-23

Material Format: Digital

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Name of awarding university/degree: 新潟大学,博士(歯学)

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Note (General)：: Psychophysical stress could increase nociception in the orofacial region including the masseter muscle, and neural changes in the brain contribute to ...

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Material Type: 博士論文
Title: Modulatory effects of repeated psychophysical stress on masseter muscle nociception in the nucleus raphe magnus of rats
Author/Editor: Shimizu, Shiho
Publication Date: 2020-03-23
Publication Date (W3CDTF): 2020-03-23
Alternative Title: 情動ストレスは大縫線核(NRM)での咬筋侵害応答を増大させる
Degree grantor/type: 新潟大学
Date Granted: 2020-03-23
Date Granted (W3CDTF): 2020-03-23
Dissertation Number: 甲第4724号
Degree Type: 博士(歯学)
Conferring No. (Dissertation): 甲第4724号
Text Language Code: eng
Subject Heading: pain
nucleus raphe magnus
repeated forced swim stress
masseter muscle
serotonin
rostral ventromedial medulla
Note (General): Psychophysical stress could increase nociception in the orofacial region including the masseter muscle, and neural changes in the brain contribute to increases in masseter muscle nociception under psychophysical stress conditions. The nucleus raphe magnus (NRM) located in the brain stem serves crucial roles to regulate nociception as descending pain controls. However, it remains unclear if neural activities in the NRM could be affected under psychophysical stress conditions. This study conducted experiments to assess (1) whether neural activity, indicated by Fos expression in the NRM evoked by masseter muscle injury, is modulated by the repeated forced swim stress (FST); (2) whether the selective serotonin reuptake inhibitor, fluoxetine, administered daily after FST could affect the number of Fos-positive neurons in the NRM. Results revealed that repeated forced swim stress significantly increased the number of Fos-positive neurons in the NRM evoked by masseter muscle injury. Fluoxetine inhibited increases in the number of Fos-positive neurons in the NRM in FST, but not in sham rats. These findings indicated that FST could increase in nociceptive neural activities in the NRM evoked by masseter muscle injury, which could be due to changes in serotonergic mechanisms at least, in part.
Journal of Oral Science. 2020, 62(2), 231-235.
新大院博(歯)甲第448号
開始ページ : 1
終了ページ : 15
DOI: info:doi/10.2334/josnusd.19-0320
https://doi.org/info:doi/10.2334/josnusd.19-0320
Persistent ID (NDL): info:ndljp/pid/11538577
https://dl.ndl.go.jp/pid/11538577
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2020-09-07T06:04:08+09:00
Date Created (W3CDTF): 2020-08-31
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://hdl.handle.net/10191/00051741
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
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