並列タイトル等Integrinβ1を介したPLOD2による頭頸部癌浸潤・転移制御機構の解析
一般注記Identifying the specific functional regulator of integrin family molecules in cancer cells is critical because they are directly involved in tumor invasion and metastasis. Here we report high expression of PLOD2 in oropharyngeal squamous cell carcinomas (SCCs) and its critical role as a stabilizer of integrin b1, enabling integrin b1 to initiate tumor invasion/metastasis. Integrin b1 stabilized by PLOD2-mediated hydroxylation was recruited to the plasma membrane, its functional site, and accelerated tumor cell motility, leading to tumor metastasis in vivo, whereas loss of PLOD2 expression abrogated it. In accordance with molecular analysis, examination of oropharyngeal SCC tissues from patients corroborated PLOD2 expression associated with integrin b1 at the invasive front of tumor nests. PLOD2 is thus implicated as the key regulator of integrin b1 that prominently regulates tumor invasion and metastasis, and it provides important clues engendering novel therapeutics for these intractable cancers.
iScience. 2020, 23(2), 100850.
新大院博(医)甲第930号
元資料の権利情報 : 【○!C】 2020 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
DOIinfo:doi/10.1016/j.isci.2020.100850
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