PLOD2 Is Essential to Functional Activation of Integrin β1 for Invasion/Metastasis in Head and Neck Squamous Cell Carcinomas

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PLOD2 Is Essential to Functional Activation of Integrin β1 for Invasion/Metastasis in Head and Neck Squamous Cell Carcinomas

Persistent ID (NDL): info:ndljp/pid/11538622

Material type: 博士論文

Author: Ueki, Yushi

Publisher: -

Publication date: 2020-03-23

Material Format: Digital

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Name of awarding university/degree: 新潟大学,博士(医学)

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Note (General)：: Identifying the specific functional regulator of integrin family molecules in cancer cells is critical because they are directly involved in tumor inv...

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Material Type: 博士論文
Title: PLOD2 Is Essential to Functional Activation of Integrin β1 for Invasion/Metastasis in Head and Neck Squamous Cell Carcinomas
Author/Editor: Ueki, Yushi
Publication Date: 2020-03-23
Publication Date (W3CDTF): 2020-03-23
Alternative Title: Integrinβ1を介したPLOD2による頭頸部癌浸潤・転移制御機構の解析
Degree grantor/type: 新潟大学
Date Granted: 2020-03-23
Date Granted (W3CDTF): 2020-03-23
Dissertation Number: 甲第4696号
Degree Type: 博士(医学)
Conferring No. (Dissertation): 甲第4696号
Text Language Code: eng
Note (General): Identifying the specific functional regulator of integrin family molecules in cancer cells is critical because they are directly involved in tumor invasion and metastasis. Here we report high expression of PLOD2 in oropharyngeal squamous cell carcinomas (SCCs) and its critical role as a stabilizer of integrin b1, enabling integrin b1 to initiate tumor invasion/metastasis. Integrin b1 stabilized by PLOD2-mediated hydroxylation was recruited to the plasma membrane, its functional site, and accelerated tumor cell motility, leading to tumor metastasis in vivo, whereas loss of PLOD2 expression abrogated it. In accordance with molecular analysis, examination of oropharyngeal SCC tissues from patients corroborated PLOD2 expression associated with integrin b1 at the invasive front of tumor nests. PLOD2 is thus implicated as the key regulator of integrin b1 that prominently regulates tumor invasion and metastasis, and it provides important clues engendering novel therapeutics for these intractable cancers.
iScience. 2020, 23(2), 100850.
新大院博(医)甲第930号
元資料の権利情報 : 【○!C】 2020 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
DOI: info:doi/10.1016/j.isci.2020.100850
https://doi.org/info:doi/10.1016/j.isci.2020.100850
Persistent ID (NDL): info:ndljp/pid/11538622
https://dl.ndl.go.jp/pid/11538622
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2020-09-07T06:04:08+09:00
Date Created (W3CDTF): 2020-08-31
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://hdl.handle.net/10191/00051819
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
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