Abundance of mitochondrial superoxide dismutase is a negative predictive biomarker for endometriosis-associated ovarian cancers.

• 資料種別: 博士論文
• ISSN: 1477-7819
• タイトル: Abundance of mitochondrial superoxide dismutase is a negative predictive biomarker for endometriosis-associated ovarian cancers.
• 巻次・部編番号: 17 1
• 著者・編者: 天野, 創; AMANO, Tsukuru
• 著者標目: 天野, 創; AMANO, Tsukuru
• 出版事項: BioMed Central
• 出版年月日等: 2019-01-30
• 出版年（W3CDTF）: 2019-01-30
• タイトル（掲載誌）: World Journal of Surgical Oncology
• 授与機関名: 滋賀医科大学
• 授与年月日: 2019-09-11
• 授与年月日（W3CDTF）: 2019-09-11
• 報告番号: 乙第445号
• 学位: 博士（医学）
• 博論授与番号: 乙第445号
• 本文の言語コード: eng
• 件名標目: Clear cell ovarian carcinoma; Endometrioid ovarian carcinoma; Endometriosis-associated ovarian cancer; Mitochondrial superoxide dismutase
• 対象利用者: 一般
• 一般注記: Background:Endometrioid ovarian carcinoma and clear cell ovarian carcinoma are both classified as endometriosis-associated ovarian cancers (EAOCs). Despite the high rates of recurrence and mortality of EAOC, only a few prognostic biomarkers have been reported. Mitochondrial superoxide dismutase (SOD2) plays an important role in maintaining mitochondrial function through oxidative stress tolerance and contributes to chemotherapeutic resistance.; Methods:To clarify the clinical significance of SOD2 in EAOC, SOD2 expression was semi-quantitatively investigated by immunohistochemical analysis in 61 primary EAOC cases, and the correlations between SOD2 expression and clinicopathological data and survival were analyzed.; Results:Forty-six (75%) cases expressed high levels of SOD2. High SOD2 expression was associated with a poor prognosis on both univariate and multivariate analyses after adjusting for variables such as age, International Federation of Gynecology and Obstetrics (FIGO) stage, blood markers, histological type, and completion of treatment. There were 14 fatalities from 15 recurrences among 46 cases with high SOD2 expression. In contrast, only one recurrence and no fatalities were seen among 15 cases with low SOD2 expression.; Conclusion:Increased SOD2 expression is a predictive biomarker for worse prognosis in EAOC. The therapeutic efficacy of the current standard therapeutic protocol for EAOC is limited; thus, mitochondrial SOD2 should be a therapeutic target for SOD2-abundant EAOC.; Thesis or Dissertation; 令和元年度; 10.1186/s12957-019-1565-0; 博士論文要旨
• DOI: info:doi/10.1186/s12957-019-1565-0; https://doi.org/info:doi/10.1186/s12957-019-1565-0
• 国立国会図書館永続的識別子: info:ndljp/pid/11551849; https://dl.ndl.go.jp/pid/11551849
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2020-10-06T21:18:06+09:00
• 作成日（W3CDTF）: 2020-09-17
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 関連情報（URI）: http://hdl.handle.net/10422/00012671
• 掲載誌（URI）: http://hdl.handle.net/10422/00012798; https://shiga-med.repo.nii.ac.jp/records/3684
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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