Abundance of mitochondrial superoxide dismutase is a negative predictive biomarker for endometriosis-associated ovarian cancers. 1

• Material Type: 博士論文
• ISSN: 1477-7819
• Title: Abundance of mitochondrial superoxide dismutase is a negative predictive biomarker for endometriosis-associated ovarian cancers.
• Volume: 17 1
• Author/Editor: 天野, 創; AMANO, Tsukuru
• Author Heading: 天野, 創; AMANO, Tsukuru
• Publication, Distribution, etc.: BioMed Central
• Publication Date: 2019-01-30
• Publication Date (W3CDTF): 2019-01-30
• Periodical title: World Journal of Surgical Oncology
• Degree grantor/type: 滋賀医科大学
• Date Granted: 2019-09-11
• Date Granted (W3CDTF): 2019-09-11
• Dissertation Number: 乙第445号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 乙第445号
• Text Language Code: eng
• Subject Heading: Clear cell ovarian carcinoma; Endometrioid ovarian carcinoma; Endometriosis-associated ovarian cancer; Mitochondrial superoxide dismutase
• Target Audience: 一般
• Note (General): Background:Endometrioid ovarian carcinoma and clear cell ovarian carcinoma are both classified as endometriosis-associated ovarian cancers (EAOCs). Despite the high rates of recurrence and mortality of EAOC, only a few prognostic biomarkers have been reported. Mitochondrial superoxide dismutase (SOD2) plays an important role in maintaining mitochondrial function through oxidative stress tolerance and contributes to chemotherapeutic resistance.; Methods:To clarify the clinical significance of SOD2 in EAOC, SOD2 expression was semi-quantitatively investigated by immunohistochemical analysis in 61 primary EAOC cases, and the correlations between SOD2 expression and clinicopathological data and survival were analyzed.; Results:Forty-six (75%) cases expressed high levels of SOD2. High SOD2 expression was associated with a poor prognosis on both univariate and multivariate analyses after adjusting for variables such as age, International Federation of Gynecology and Obstetrics (FIGO) stage, blood markers, histological type, and completion of treatment. There were 14 fatalities from 15 recurrences among 46 cases with high SOD2 expression. In contrast, only one recurrence and no fatalities were seen among 15 cases with low SOD2 expression.; Conclusion:Increased SOD2 expression is a predictive biomarker for worse prognosis in EAOC. The therapeutic efficacy of the current standard therapeutic protocol for EAOC is limited; thus, mitochondrial SOD2 should be a therapeutic target for SOD2-abundant EAOC.; Thesis or Dissertation; 令和元年度; 10.1186/s12957-019-1565-0; 博士論文要旨
• DOI: info:doi/10.1186/s12957-019-1565-0; https://doi.org/info:doi/10.1186/s12957-019-1565-0
• Persistent ID (NDL): info:ndljp/pid/11551849; https://dl.ndl.go.jp/pid/11551849
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2020-10-06T21:18:06+09:00
• Date Created (W3CDTF): 2020-09-17
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Related Material (URI): http://hdl.handle.net/10422/00012671
• Periodical Title (URI): http://hdl.handle.net/10422/00012798; https://shiga-med.repo.nii.ac.jp/records/3684
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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