Disequilibrium of Plasma Protease/Anti-Protease Due to Severe Periodontal Disease Contributes to Human Subarachnoid Hemorrhage 3

• 資料種別: 博士論文
• ISSN: 2633-0873
• タイトル: Disequilibrium of Plasma Protease/Anti-Protease Due to Severe Periodontal Disease Contributes to Human Subarachnoid Hemorrhage
• 巻次・部編番号: 1 3
• 著者・編者: Yoshioka, Shotaro; Miyamoto, Takeshi; Satomi, Junichiro; Tada, Yoshiteru; Yagi, Kenji; Shimada, Kenji; Naruishi, Koji; Shikata, Eiji; Yamaguchi, Izumi; Yamaguchi, Tadashi; Korai, Masaaki; Okayama, Yoshihiro; Harada, Masafumi; Kitazato, Keiko T.; Kanematsu, Yasuhisa; Nagahiro, Shinji; Takagi, Yasushi
• 著者標目: Yoshioka, Shotaro; Miyamoto, Takeshi; Satomi, Junichiro; Tada, Yoshiteru; Yagi, Kenji; Shimada, Kenji; Naruishi, Koji; Shikata, Eiji; Yamaguchi, Izumi; Yamaguchi, Tadashi; Korai, Masaaki; Okayama, Yoshihiro; Harada, Masafumi; Kitazato, Keiko T.; Kanematsu, Yasuhisa; Nagahiro, Shinji; Takagi, Yasushi
• 出版事項: Oxford University Press|Congress of Neurological Surgeons
• 出版年月日等: 2020-07-17
• 出版年（W3CDTF）: 2020-07-17
• 並列タイトル等: 重症歯周病に起因する血中蛋白分解酵素とその阻害因子の不均衡はヒトの脳動脈瘤破裂に関与する; RUPTURED CEREBRAL ANEURYSMS AND SEVERE PD
• タイトル（掲載誌）: Neurosurgery Open
• 授与機関名: 徳島大学
• 授与年月日: 2020-09-10
• 授与年月日（W3CDTF）: 2020-09-10
• 報告番号: 甲第3431号
• 学位: 博士（医学）
• 博論授与番号: 甲第3431号
• 本文の言語コード: eng
• 件名標目: gingival bleeding; intracranial aneurysm; matrix metalloproteinase 9; periodontal disease; procollagen type I; Subarachnoid hemorrhage; Tissue inhibitor of metalloproteinase 2
• 対象利用者: 一般
• 一般注記: BACKGROUND: The pathophysiology of subarachnoid hemorrhages (SAHs) due to ruptured intracranial aneurysms (IAs) remains unclear.Although a relationship between SAHs and periodontal disease (PD) has been suggested, the mechanism requires clarification.OBJECTIVE: To evaluate the relationship between PD and SAHs and to identify periodontal pathogens associated with SAHs.METHODS: This prospective study included consecutive patients with ruptured (n = 11) and unruptured (n = 14) IAs and healthy controls (n = 8). The plasma and plaque subgingival bacterial deoxyribonucleic acid (DNA) levels in PD were evaluated by a dentist using the Community Periodontal Index of Treatment Needs (CPITN). Plasma levels of matrix metalloproteinase (MMP-9), tissue inhibitors of matrix metalloproteinase (TIMP2), and procollagen I were analyzed.RESULTS: Patients with ruptured IAs, had significantly higher CPITN scores than the controls, suggesting that ruptured IAs were associated with severe PD. Although no rupture-specific bacteria were identified, the positive rate of plaque subgingival bacterial DNA was significantly higher in patients with severe PD than in those without severe PD. Multivariate logistic regression analysis indicated that bleeding on probing (BOP)was associated with ruptured IAs (odds ratio, 1.10; 95% confidence interval 1.04–1.20; P = .0001). BOP was positively associated with plasma MMP-9 levels and a disequilibrium in the MMP-9/TIMP2 ratio. BOP was negatively correlated with plasma procollagen I levels (P < .05, for each). This suggested that local inflammation with severe PD might have systemic effects and lead to ruptured IAs.CONCLUSION: Disequilibrium of plasma protease/anti-protease associated with a high BOP rate in severe PD may be attributable to IA rupture.
• DOI: info:doi/10.1093/neuopn/okaa007; https://doi.org/info:doi/10.1093/neuopn/okaa007
• 国立国会図書館永続的識別子: info:ndljp/pid/11552099; https://dl.ndl.go.jp/pid/11552099
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2020-10-06T21:18:06+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://repo.lib.tokushima-u.ac.jp/115292
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp