Disequilibrium of Plasma Protease/Anti-Protease Due to Severe Periodontal Disease Contributes to Human Subarachnoid Hemorrhage 1 3

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Disequilibrium of Plasma Protease/Anti-Protease Due to Severe Periodontal Disease Contributes to Human Subarachnoid Hemorrhage 3

Persistent ID (NDL): info:ndljp/pid/11552099

Material type: 博士論文

Author: Yoshioka, Shotaroほか

Publisher: Oxford University Press|Congress of Neurological Surgeons

Publication date: 2020-07-17

Material Format: Digital

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Name of awarding university/degree: 徳島大学,博士（医学）

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Note (General)：: BACKGROUND: The pathophysiology of subarachnoid hemorrhages (SAHs) due to ruptured intracranial aneurysms (IAs) remains unclear.Although a relationshi...

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Material Type: 博士論文
ISSN: 2633-0873
Title: Disequilibrium of Plasma Protease/Anti-Protease Due to Severe Periodontal Disease Contributes to Human Subarachnoid Hemorrhage
Volume: 1 3
Author/Editor: Yoshioka, Shotaro
Miyamoto, Takeshi
Satomi, Junichiro
Tada, Yoshiteru
Yagi, Kenji
Shimada, Kenji
Naruishi, Koji
Shikata, Eiji
Yamaguchi, Izumi
Yamaguchi, Tadashi
Korai, Masaaki
Okayama, Yoshihiro
Harada, Masafumi
Kitazato, Keiko T.
Kanematsu, Yasuhisa
Nagahiro, Shinji
Takagi, Yasushi
Author Heading: Yoshioka, Shotaro
Miyamoto, Takeshi
Satomi, Junichiro
Tada, Yoshiteru
Yagi, Kenji
Shimada, Kenji
Naruishi, Koji
Shikata, Eiji
Yamaguchi, Izumi
Yamaguchi, Tadashi
Korai, Masaaki
Okayama, Yoshihiro
Harada, Masafumi
Kitazato, Keiko T.
Kanematsu, Yasuhisa
Nagahiro, Shinji
Takagi, Yasushi
Publication, Distribution, etc.: Oxford University Press|Congress of Neurological Surgeons
Publication Date: 2020-07-17
Publication Date (W3CDTF): 2020-07-17
Alternative Title: 重症歯周病に起因する血中蛋白分解酵素とその阻害因子の不均衡はヒトの脳動脈瘤破裂に関与する
RUPTURED CEREBRAL ANEURYSMS AND SEVERE PD
Periodical title: Neurosurgery Open
Degree grantor/type: 徳島大学
Date Granted: 2020-09-10
Date Granted (W3CDTF): 2020-09-10
Dissertation Number: 甲第3431号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第3431号
Text Language Code: eng
Subject Heading: gingival bleeding
intracranial aneurysm
matrix metalloproteinase 9
periodontal disease
procollagen type I
Subarachnoid hemorrhage
Tissue inhibitor of metalloproteinase 2
Target Audience: 一般
Note (General): BACKGROUND: The pathophysiology of subarachnoid hemorrhages (SAHs) due to ruptured intracranial aneurysms (IAs) remains unclear.Although a relationship between SAHs and periodontal disease (PD) has been suggested, the mechanism requires clarification.OBJECTIVE: To evaluate the relationship between PD and SAHs and to identify periodontal pathogens associated with SAHs.METHODS: This prospective study included consecutive patients with ruptured (n = 11) and unruptured (n = 14) IAs and healthy controls (n = 8). The plasma and plaque subgingival bacterial deoxyribonucleic acid (DNA) levels in PD were evaluated by a dentist using the Community Periodontal Index of Treatment Needs (CPITN). Plasma levels of matrix metalloproteinase (MMP-9), tissue inhibitors of matrix metalloproteinase (TIMP2), and procollagen I were analyzed.RESULTS: Patients with ruptured IAs, had significantly higher CPITN scores than the controls, suggesting that ruptured IAs were associated with severe PD. Although no rupture-specific bacteria were identified, the positive rate of plaque subgingival bacterial DNA was significantly higher in patients with severe PD than in those without severe PD. Multivariate logistic regression analysis indicated that bleeding on probing (BOP)was associated with ruptured IAs (odds ratio, 1.10; 95% confidence interval 1.04–1.20; P = .0001). BOP was positively associated with plasma MMP-9 levels and a disequilibrium in the MMP-9/TIMP2 ratio. BOP was negatively correlated with plasma procollagen I levels (P < .05, for each). This suggested that local inflammation with severe PD might have systemic effects and lead to ruptured IAs.CONCLUSION: Disequilibrium of plasma protease/anti-protease associated with a high BOP rate in severe PD may be attributable to IA rupture.
DOI: info:doi/10.1093/neuopn/okaa007
https://doi.org/info:doi/10.1093/neuopn/okaa007
Persistent ID (NDL): info:ndljp/pid/11552099
https://dl.ndl.go.jp/pid/11552099
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2020-10-06T21:18:06+09:00
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/115292
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp