Anti-PD-1 antibody combined with chemotherapy suppresses the growth of mesothelioma by reducing myeloid-derived suppressor cells

• 資料種別: 博士論文
• ISSN: 0169-5002
• タイトル: Anti-PD-1 antibody combined with chemotherapy suppresses the growth of mesothelioma by reducing myeloid-derived suppressor cells
• 巻次・部編番号: 146
• 著者・編者: Otsuka, Kenji; Mitsuhashi, Atsushi; Goto, Hisatsugu; Hanibuchi, Masaki; Koyama, Kazuya; Ogawa, Hirohisa; Ogino, Hirokazu; Saijo, Atsuro; Kozai, Hiroyuki; Yoneda, Hiroto; Tobiume, Makoto; Kishuku, Masatoshi; Ishizawa, Keisuke; Nishioka, Yasuhiko
• 著者標目: Otsuka, Kenji; Mitsuhashi, Atsushi; Goto, Hisatsugu; Hanibuchi, Masaki; Koyama, Kazuya; Ogawa, Hirohisa; Ogino, Hirokazu; Saijo, Atsuro; Kozai, Hiroyuki; Yoneda, Hiroto; Tobiume, Makoto; Kishuku, Masatoshi; Ishizawa, Keisuke; Nishioka, Yasuhiko
• 出版事項: Elsevier
• 出版年月日等: 2020-05-21
• 出版年（W3CDTF）: 2020-05-21
• 並列タイトル等: 抗PD-1抗体への化学療法の併用はmyeloid-derived suppressor cellsを減少させることにより中皮腫の増殖を抑制する
• タイトル（掲載誌）: Lung Cancer
• 授与機関名: 徳島大学
• 授与年月日: 2020-09-24
• 授与年月日（W3CDTF）: 2020-09-24
• 報告番号: 甲第3457号
• 学位: 博士（医学）
• 博論授与番号: 甲第3457号
• 本文の言語コード: eng
• 件名標目: Lung cancer; Malignant pleural mesothelioma; PD-1; MDSC; VEGF
• 対象利用者: 一般
• 一般注記: Background: The combination of anti-PD-1/PD-L1 antibody with chemotherapy has been approved for the first-line therapy of lung cancer. However, the effects against malignant mesothelioma (MPM) and the immunological mechanisms by which chemotherapy enhances the effect of targeting PD-1/PD-L1 in MPM are poorly understood.Materials and Methods: We utilized syngeneic mouse models of MPM and lung cancer and assessed the therapeutic effects of anti-PD-1 antibody and its combination with cisplatin (CDDP) and pemetrexed (PEM). An immunological analysis of tumor-infiltrating cells was performed with immunohistochemistry.Results: We observed significant therapeutic effects of anti-PD-1 antibody against MPM. Although the effect was associated with CD8+ and CD4+ T cells in tumors, the number of Foxp3+ cells was not reduced but rather increased. Consequently, combination with CDDP/PEM significantly enhanced the antitumor effects of anti-PD-1 antibody by decreasing numbers of intratumoral myeloid-derived suppressor cells (MDSCs) and vessels probably through suppression of VEGF expression by CDDP+PEM.Conclusions: The combination of anti-PD-1 antibody with CDDP+PEM may be a promising therapy for MPM via inhibiting the accumulation of MDSCs and vessels in tumors.
• DOI: info:doi/10.1016/j.lungcan.2020.05.023; https://doi.org/info:doi/10.1016/j.lungcan.2020.05.023
• 国立国会図書館永続的識別子: info:ndljp/pid/11570279; https://dl.ndl.go.jp/pid/11570279
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2020-11-10T19:58:22+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://repo.lib.tokushima-u.ac.jp/115324
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp