Anti-PD-1 antibody combined with chemotherapy suppresses the growth of mesothelioma by reducing myeloid-derived suppressor cells

• Material Type: 博士論文
• ISSN: 0169-5002
• Title: Anti-PD-1 antibody combined with chemotherapy suppresses the growth of mesothelioma by reducing myeloid-derived suppressor cells
• Volume: 146
• Author/Editor: Otsuka, Kenji; Mitsuhashi, Atsushi; Goto, Hisatsugu; Hanibuchi, Masaki; Koyama, Kazuya; Ogawa, Hirohisa; Ogino, Hirokazu; Saijo, Atsuro; Kozai, Hiroyuki; Yoneda, Hiroto; Tobiume, Makoto; Kishuku, Masatoshi; Ishizawa, Keisuke; Nishioka, Yasuhiko
• Author Heading: Otsuka, Kenji; Mitsuhashi, Atsushi; Goto, Hisatsugu; Hanibuchi, Masaki; Koyama, Kazuya; Ogawa, Hirohisa; Ogino, Hirokazu; Saijo, Atsuro; Kozai, Hiroyuki; Yoneda, Hiroto; Tobiume, Makoto; Kishuku, Masatoshi; Ishizawa, Keisuke; Nishioka, Yasuhiko
• Publication, Distribution, etc.: Elsevier
• Publication Date: 2020-05-21
• Publication Date (W3CDTF): 2020-05-21
• Alternative Title: 抗PD-1抗体への化学療法の併用はmyeloid-derived suppressor cellsを減少させることにより中皮腫の増殖を抑制する
• Periodical title: Lung Cancer
• Degree grantor/type: 徳島大学
• Date Granted: 2020-09-24
• Date Granted (W3CDTF): 2020-09-24
• Dissertation Number: 甲第3457号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第3457号
• Text Language Code: eng
• Subject Heading: Lung cancer; Malignant pleural mesothelioma; PD-1; MDSC; VEGF
• Target Audience: 一般
• Note (General): Background: The combination of anti-PD-1/PD-L1 antibody with chemotherapy has been approved for the first-line therapy of lung cancer. However, the effects against malignant mesothelioma (MPM) and the immunological mechanisms by which chemotherapy enhances the effect of targeting PD-1/PD-L1 in MPM are poorly understood.Materials and Methods: We utilized syngeneic mouse models of MPM and lung cancer and assessed the therapeutic effects of anti-PD-1 antibody and its combination with cisplatin (CDDP) and pemetrexed (PEM). An immunological analysis of tumor-infiltrating cells was performed with immunohistochemistry.Results: We observed significant therapeutic effects of anti-PD-1 antibody against MPM. Although the effect was associated with CD8+ and CD4+ T cells in tumors, the number of Foxp3+ cells was not reduced but rather increased. Consequently, combination with CDDP/PEM significantly enhanced the antitumor effects of anti-PD-1 antibody by decreasing numbers of intratumoral myeloid-derived suppressor cells (MDSCs) and vessels probably through suppression of VEGF expression by CDDP+PEM.Conclusions: The combination of anti-PD-1 antibody with CDDP+PEM may be a promising therapy for MPM via inhibiting the accumulation of MDSCs and vessels in tumors.
• DOI: info:doi/10.1016/j.lungcan.2020.05.023; https://doi.org/info:doi/10.1016/j.lungcan.2020.05.023
• Persistent ID (NDL): info:ndljp/pid/11570279; https://dl.ndl.go.jp/pid/11570279
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2020-11-10T19:58:22+09:00
• Format (IMT): application/pdf
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• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/115324
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp