Unique hemoglobin dynamics in female Tibetan highlanders

• 資料種別: 記事
• タイトル: Unique hemoglobin dynamics in female Tibetan highlanders
• 著者・編者: Hiroaki Arima; Masayuki Nakano; Sweta Koirala
• 出版事項: 日本 : Springer Nature
• 出版年月日等: 2021-01-04
• 出版年（W3CDTF）: 2021-01-04
• タイトル（掲載誌）: Tropical medicine and health
• 巻号年月日等（掲載誌）: 49(2)
• 掲載巻: 49(2)
• ISSN（掲載誌）: 1349-4147
• ISSN-L（掲載誌）: 1348-8945
• 本文の言語コード: eng
• DOI: 10.1186/s41182-020-00289-6; https://doi.org/10.1186/s41182-020-00289-6
• 国立国会図書館永続的識別子: info:ndljp/pid/11667859; https://dl.ndl.go.jp/pid/11667859
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > 電子書籍・電子雑誌 > その他; https://dl.ndl.go.jp/collections/B00035
• 収集根拠: オンライン資料収集制度
• 受理日（W3CDTF）: 2021-04-28T11:35:34+09:00
• 保存日（W3CDTF）: 2021-04-28
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: https://tropmedhealth.biomedcentral.com/articles
• 掲載誌（国立国会図書館永続的識別子）: info:ndljp/pid/11667857; https://dl.ndl.go.jp/pid/11667857
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

• 要約等: Background: Tibetan highlanders have adapted to hypoxic environments through the development of unique mechanisms that suppress an increase in hemoglobin (Hb) concentration even in high-altitude areas. Hb concentrations generally decrease with increasing age. However, in the highlands, chronic altitude sickness is known to occur in the elderly population. To investigate how aging in a hypoxic environment affects Hb levels in Tibetan highlanders, we focused on the Mustang people, who live above 3500 m. We tried to clarify the pure relationship between aging and Hb levels in a hypoxic environment.Results: We found that the Hb concentration increased with increasing age in females but not in males. Multivariate analysis showed that age, pulse pressure, the poverty index, and vascular diameter were strongly correlated with the Hb concentration. Conclusions: We found unique Hb dynamics among female Tibetan highlanders. As seen in these Hb dynamics, there may be sex-based differences in the adaptive mechanism in Tibetan highlanders.; Tropical Medicine and Health, 49(1), art.no.2; 2020
• DOI: 10.1186/s41182-020-00289-6; https://doi.org/10.1186/s41182-020-00289-6
• オンライン閲覧公開範囲: インターネット公開
• 著作権情報: © 2021, The Author(s). Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you giveappropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate ifchanges were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
• 関連情報（URI）: http://hdl.handle.net/10069/00040473; https://nagasaki-u.repo.nii.ac.jp/records/26270; http://id.ndl.go.jp/digimeta/11667859; https://dl.ndl.go.jp/pid/11667859; http://link.springer.com/content/pdf/10.1186/s41182-020-00289-6.pdf; http://link.springer.com/article/10.1186/s41182-020-00289-6/fulltext.html; https://search.jamas.or.jp/link/ui/2023194204
• 参照: Sex differences in genotype frequency and the risk of polycythemia associated with rs13419896 and rs2790859 among Tibetan highlanders living in Tsarang, Mustang, Nepal; https://cir.nii.ac.jp/crid/1050020552344491136; High prevalence of rheumatoid arthritis and its risk factors among Tibetan highlanders living in Tsarang, Mustang district of Nepal; https://cir.nii.ac.jp/crid/1050854882729888512; Individual variations and sex differences in hemodynamics and percutaneous arterial oxygen saturation (SpO2) in Tibetan highlanders of Tsarang in the Mustang district of Nepal; https://cir.nii.ac.jp/crid/1360579811521667712
• 参照: Glucose intolerance associated with hypoxia in people living at high altitudes in the Tibetan highland; https://cir.nii.ac.jp/crid/1050001335835697280; Genetic Variants in EPAS1 Contribute to Adaptation to High-Altitude Hypoxia in Sherpas; https://cir.nii.ac.jp/crid/1050564288867620096; The overlooked significance of plasma volume for successful adaptation to high altitude in Sherpa and Andean natives; https://cir.nii.ac.jp/crid/1360011144240153472; <i>EPAS1</i> Gene Polymorphisms Are Associated With High Altitude Polycythemia in Tibetans at the Qinghai-Tibetan Plateau; https://cir.nii.ac.jp/crid/1360011146340637568; Screening and treatment of hypertension in older adults: less is more?; https://cir.nii.ac.jp/crid/1360013171607424256; Cardiovascular Medicine at High Altitude; https://cir.nii.ac.jp/crid/1360013171742455168; Age-related changes in peripheral blood counts in humans; https://cir.nii.ac.jp/crid/1360013172400699136; The earliest human occupation of the high-altitude Tibetan Plateau 40 thousand to 30 thousand years ago; https://cir.nii.ac.jp/crid/1360013172662738688; Frequency of Polycythemia and Other Abnormalities in a Tibetan Herdsmen Population Residing in the Kham Area of Sichuan Province, China; https://cir.nii.ac.jp/crid/1360294645592466304; High altitude genetic adaptation in Tibetans: No role of increased hemoglobin–oxygen affinity; https://cir.nii.ac.jp/crid/1360294646685712000; Regional aortic distensibility and its relationship with age and aortic stenosis: a computed tomography study; https://cir.nii.ac.jp/crid/1360294647356603520; Human adaptation to high altitude: Regional and life-cycle perspectives; https://cir.nii.ac.jp/crid/1360574093674427648; Detecting past and ongoing natural selection among ethnically Tibetan women at high altitude in Nepal; https://cir.nii.ac.jp/crid/1360576121918423936; Prevalence of oxygen desaturation and use of oxygen at home in adults at sea level and at moderate altitude; https://cir.nii.ac.jp/crid/1360576122107115904; What is the most important component of blood pressure: systolic, diastolic or pulse pressure?; https://cir.nii.ac.jp/crid/1360576122682963712; Molecular Sex Differences in Human Serum; https://cir.nii.ac.jp/crid/1360576123100777216; Health Effects of Overweight and Obesity in 195 Countries over 25 Years; https://cir.nii.ac.jp/crid/1360855569741750016; Prevalence of Stroke at High Altitude (3380 m) in Cuzco, a Town of Peru; https://cir.nii.ac.jp/crid/1360857596535828352; Middle Stone Age foragers resided in high elevations of the glaciated Bale Mountains, Ethiopia; https://cir.nii.ac.jp/crid/1360857596885727616; Beyond medicine and lifestyle: addressing the societal determinants of cardiovascular disease in North America; https://cir.nii.ac.jp/crid/1360857596913685376; Significant Heritages of Upper Mustang and Issue of Conservation; https://cir.nii.ac.jp/crid/1360857597077307136; Paleoindian settlement of the high-altitude Peruvian Andes; https://cir.nii.ac.jp/crid/1361137045481938432; Andean, Tibetan, and Ethiopian patterns of adaptation to high-altitude hypoxia; https://cir.nii.ac.jp/crid/1361137045662885632; Higher blood flow and circulating NO products offset high-altitude hypoxia among Tibetans; https://cir.nii.ac.jp/crid/1361418519212723328; Ancestral Origins and Genetic History of Tibetan Highlanders; https://cir.nii.ac.jp/crid/1361418520585503104; Influence of vascular dimension on gender difference in flow-dependent dilatation of peripheral conduit arteries; https://cir.nii.ac.jp/crid/1361699996307222272; Human Genetic Adaptation to High Altitude; https://cir.nii.ac.jp/crid/1361981468984260864; The Impact of Gender on Vessel Size in Patients with Angiographically Normal Coronary Arteries; https://cir.nii.ac.jp/crid/1362262944167138560; The sex difference in haemoglobin levels in adults — Mechanisms, causes, and consequences; https://cir.nii.ac.jp/crid/1362825894351238272; A genetic mechanism for Tibetan high-altitude adaptation; https://cir.nii.ac.jp/crid/1363107369289497728; Sex and gender differences in health; https://cir.nii.ac.jp/crid/1363107370201305856; Gender Differences in the Regulation of Blood Pressure; https://cir.nii.ac.jp/crid/1363388845746387200; Comprehensive geriatric assessment of elderly highlanders in Qinghai, China II: The association of polycythemia with lifestyle‐related diseases among the three ethnicities; https://cir.nii.ac.jp/crid/1363670319985284096
• 連携機関・データベース: 国立情報学研究所 : CiNii Research; https://cir.nii.ac.jp/
• 提供元機関・データベース: 学術機関リポジトリデータベース; https://irdb.nii.ac.jp; 雑誌記事索引データベース; https://ndlsearch.ndl.go.jp; Crossref; https://www.crossref.org; CiNii Articles; 科学研究費助成事業データベース; https://kaken.nii.ac.jp/ja
• 書誌ID（NDLBibID）: 11667859; http://id.ndl.go.jp/bib/11667859
• NII論文ID: 120006956200