Partially hydrolyzed guar gum alleviates small intestinal mucosal damage after massive small bowel resection along with changes in the intestinal microbiota.

• 資料種別: 博士論文
• タイトル: Partially hydrolyzed guar gum alleviates small intestinal mucosal damage after massive small bowel resection along with changes in the intestinal microbiota.
• 著者・編者: 藤井, 喬之
• 著者標目: 藤井, 喬之
• 出版年月日等: 2021-03-24
• 出版年（W3CDTF）: 2021-03-24
• 並列タイトル等: グアーガム分解物による大量小腸切除後の小腸粘膜損傷の修復と腸内細菌叢の変化
• 授与機関名: 香川大学
• 授与年月日: 2021-03-24
• 授与年月日（W3CDTF）: 2021-03-24
• 報告番号: 甲第770号
• 学位: 博士（医学）
• 博論授与番号: 甲第770号
• 本文の言語コード: eng
• 著者別名: Fujii, Takayuki
• 件名標目: Partially hydrolyzed guar gum; Dietary fiber; Short bowel syndrome; Intestinal failure; Dysbosis; Short chain fatty acids
• 対象利用者: 一般
• 一般注記: Purpose: Short bowel syndrome is associated with intestinal mucosal inflammation and microbial dysbiosis, leading to intractable complications. Partially hydrolyzed guar gum (PHGG) has trophic and anti-inflammatory effects on the intestine. We investigated whether PHGG ameliorates small intestinal mucosal damage and alters the intestinal microbiota using a rat small bowel resection (SBR) model.; Methods: Sprague Dawley rats were divided into sham operation (Sham), Sham/PHGG, SBR, and SBR/PHGG groups. On day 21, all rats were euthanized. To assess small intestinal mucosal damage, the degeneration rate was morphometrically evaluated and immunohistochemically examined using anti-CD45 antibodies. Analyses of fecal microbiota using 16S rRNA and short-chain fatty acid production were also performed.; Results: The mucosal degeneration rate was significantly higher in the SBR group than in the Sham or SBR/PHGG groups. The number of CD45-positive cells was significantly higher in the SBR group than in the Sham, Sham/PHGG, or SBR/PHGG groups. The relative abundance of family Lachnospiraceae was significantly higher in the SBR/PHGG group than in the SBR group.; Conclusions: PHGG administration alleviated small intestinal mucosal damage which could be associated with modulation of the intestinal microbiota.
• DOI: info:doi/10.1016/j.jpedsurg.2019.08.048; https://doi.org/info:doi/10.1016/j.jpedsurg.2019.08.048
• 国立国会図書館永続的識別子: info:ndljp/pid/11671729; https://dl.ndl.go.jp/pid/11671729
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2021-05-16T23:51:55+09:00
• 作成日（W3CDTF）: 2021-04-22
• 記録形式（IMT）: PDF
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: https://kagawa-u.repo.nii.ac.jp/records/7336
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp