Partially hydrolyzed guar gum alleviates small intestinal mucosal damage after massive small bowel resection along with changes in the intestinal microbiota.

• Material Type: 博士論文
• Title: Partially hydrolyzed guar gum alleviates small intestinal mucosal damage after massive small bowel resection along with changes in the intestinal microbiota.
• Author/Editor: 藤井, 喬之
• Author Heading: 藤井, 喬之
• Publication Date: 2021-03-24
• Publication Date (W3CDTF): 2021-03-24
• Alternative Title: グアーガム分解物による大量小腸切除後の小腸粘膜損傷の修復と腸内細菌叢の変化
• Degree grantor/type: 香川大学
• Date Granted: 2021-03-24
• Date Granted (W3CDTF): 2021-03-24
• Dissertation Number: 甲第770号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第770号
• Text Language Code: eng
• Alias of Author: Fujii, Takayuki
• Subject Heading: Partially hydrolyzed guar gum; Dietary fiber; Short bowel syndrome; Intestinal failure; Dysbosis; Short chain fatty acids
• Target Audience: 一般
• Note (General): Purpose: Short bowel syndrome is associated with intestinal mucosal inflammation and microbial dysbiosis, leading to intractable complications. Partially hydrolyzed guar gum (PHGG) has trophic and anti-inflammatory effects on the intestine. We investigated whether PHGG ameliorates small intestinal mucosal damage and alters the intestinal microbiota using a rat small bowel resection (SBR) model.; Methods: Sprague Dawley rats were divided into sham operation (Sham), Sham/PHGG, SBR, and SBR/PHGG groups. On day 21, all rats were euthanized. To assess small intestinal mucosal damage, the degeneration rate was morphometrically evaluated and immunohistochemically examined using anti-CD45 antibodies. Analyses of fecal microbiota using 16S rRNA and short-chain fatty acid production were also performed.; Results: The mucosal degeneration rate was significantly higher in the SBR group than in the Sham or SBR/PHGG groups. The number of CD45-positive cells was significantly higher in the SBR group than in the Sham, Sham/PHGG, or SBR/PHGG groups. The relative abundance of family Lachnospiraceae was significantly higher in the SBR/PHGG group than in the SBR group.; Conclusions: PHGG administration alleviated small intestinal mucosal damage which could be associated with modulation of the intestinal microbiota.
• DOI: info:doi/10.1016/j.jpedsurg.2019.08.048; https://doi.org/info:doi/10.1016/j.jpedsurg.2019.08.048
• Persistent ID (NDL): info:ndljp/pid/11671729; https://dl.ndl.go.jp/pid/11671729
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2021-05-16T23:51:55+09:00
• Date Created (W3CDTF): 2021-04-22
• Format (IMT): PDF
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): https://kagawa-u.repo.nii.ac.jp/records/7336
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp