並列タイトル等チベット高地民の女性における特異なヘモグロビン動態
タイトル（掲載誌）Tropical Medicine and Health
授与機関名Nagasaki University (長崎大学)
一般注記Background: Tibetan highlanders have adapted to hypoxic environments through the development of unique mechanisms that suppress an increase in hemoglobin (Hb) concentration even in high-altitude areas. Hb concentrations generally decrease with increasing age. However, in the highlands, chronic altitude sickness is known to occur in the elderly population. To investigate how aging in a hypoxic environment affects Hb levels in Tibetan highlanders, we focused on the Mustang people, who live above 3500 m. We tried to clarify the pure relationship between aging and Hb levels in a hypoxic environment.Results: We found that the Hb concentration increased with increasing age in females but not in males. Multivariate analysis showed that age, pulse pressure, the poverty index, and vascular diameter were strongly correlated with the Hb concentration.Conclusions: We found unique Hb dynamics among female Tibetan highlanders. As seen in these Hb dynamics, there may be sex-based differences in the adaptive mechanism in Tibetan highlanders.
長崎大学学位論文 学位記番号:博(医歯薬)甲第1343号 学位授与年月日:令和3年3月22日
Author: Hiroaki Arima, Masayuki Nakano, Sweta Koirala, Hiromu Ito, Basu Dev Pandey, Kishor Pandey, Takayuki Wada & Taro Yamamoto
Citation: Tropical Medicine and Health, 49, art.no.2; 2021
identifier:Nagasaki University (長崎大学), 博士(医学) (2021-03-22)
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